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28 Cards in this Set
- Front
- Back
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Enters the CNS and is an antidote for Atropine toxicity
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Physostigmine
AChE inhibitor |
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Used as Tx in Alzheimers Disease
Two Drugs... |
Donepezil
Tacrine AChE inhibitors |
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Used for post-op Ileus and neurogenic urinary retention
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Bethanechol
Direct Muscarinic Agonist |
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Topical tx for Glaucoma
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Pilocarpine
Direct Muscarinic Agonist |
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Echothiophate
Malathion Parathion |
Irreversible AChE Inhibitors
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Atropine
Benztropine Ipratropium Scopolamine |
Muscarinic Blockers
Atropine/Benztropine = enter CNS |
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Tx Inhalation Asthma and COPD
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Ipratropium
M Blocker |
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Cholinergic Receptor Antagonist used for motion sickness
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Scopolamine
M Blocker |
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Adverse Effect of Cholinergic Receptor Antagonists (Muscarinic Blockers)
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Delerium in the Elderly
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Tropicamide - Use A)
Trihexyphenidyl - Use B) |
A) Topical tx in ophthamology
B) Tx in Parkinson's Disease Muscarinic Blockers |
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Phenylephrine
Methoxamine |
Alpha 1 Agonists
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Clonidine
Methyldopa |
Alpha 2 Agonists
A = MC squared |
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Isoproterenol
Dobutamine |
Adrenergic Agonists
Iso - B1=B2 Do - B1>B2 |
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Albuterol
Ritodrine Terbutaline Salmeterol |
B 2 Agonists
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Dopamine
Epinephrine Norepinephrine |
Adrenergic Agonists
Dopamine - D1 / B1 / A1 Epi - A 1,2 / B 1,2 -Low dose = B 1,2 -High dose = A1 > B 1,2 Nor - A 1,2 / B 1 |
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Tyramine
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Indirect-Acting Adrenergic Agonist
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Tamsulosin
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Alpha 1a Antagonist = BPH selective
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Yohimbine
Mirtazapine |
Alpha 2 Antagonists
Antidepressant |
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Phenoxybenzamine
Phentolamine |
Mixed Alpha Antagonists
Tx: Pheochromocytoma |
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Acebutolol
Atenolol Metoprolol |
B1 Antagonist
Cardioselective |
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Pindolol
Propranolol Timolol |
B1 / B2 Antagonist
Nonselective AE: mask effects of hypOglycemia in Insulin-Dependent (Type 1) may cause hypERglycemia in NON-Insulin Dependent (Type 2) |
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Carvedilol
Lavetalol |
Both Alpha 1 and Beta 1 Antagonists
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Where do these receptors act?
What 2nd messengers are they coupled to? M1 M2 M3 |
M1 = CNS / GI Glands
M2 = Heart M3 = Periphery M1 / M3 = Gq coupled M2 = Gi coupled |
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What are the functions of the 2nd messengers?
Gi Gq Gs |
Gi = decrease adenylyl cyclase - decrease cAMP
Gq = increase phospholipase C - increase IP3 / DAG / Ca++ Gs = increase adenylyl cyclase - increase cAMP |
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Not coupled to 2nd messengers
activation of Na+/K+ channels |
Nn and Nm
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No direct innervation on blood vessels
AChE inhibitors have no effect |
M3 receptors
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Located on prejunctional nerve terminals / platelets / pancreas
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Alpha 2 receptors
Inhibitory = decrease sympathetic flow Decrease total peripheral resistance and decrease heart rate |
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Use to reverse HTN when pt receives too much Epi
Epinephrine Reversal |
Alpha 1 Antagonists
Doxazosin Prazosin Terazosin |
