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8 Cards in this Set

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  • Back
In 1st order process, the amount of drug leaving the body is:
perportional to the amount of the drug that is available to be eliminated
In a one-compartment, 1st order process, half life:
describes the entire curve and is the same regardless of where one starts on the curve
-can be calculated graphically from curve
-is perportional to final steady state blood concentration reached
-is inversely perportional to the time it takes to reach steady state blood concentrations
In a one-compartment, first order process, the concentration of drug reached at steady state levels depends
directly upon dose and inversely upon the interval between doses
In a multi-compartment, 1st order process, if a drug is administered orally, the mean steady-state blood level:
is identical to the mean steady-state blood level by IV infusion
The elimination (1st order) half-time of drug X is five days. How many days will elapse following a single doese until approx 97% of the administereed dose is eliminated
5 half lives x 5 days = 25 days
The elimination (1st order) half time of drug X is 5 days. How many days will be necessary to achieve a plateu steady state during chronic dosage ( no loading dosage)
5 half lives x 5 = 25 days
First order processes are:
-Encountered most frequently in pharmacokinetics
-Half-time of the process is NOT dependent on drug concentration
-The process is essentially complete after 4 or 5 half-times
-The rate of the process is proportional to the drug concentration
Plateau principle
a. It takes 4 to 5 half-lives to reach the plateau drug concentration.

b. Time to reach the plateau concentration is INDIPENDANT of infusion rate or dose.

c. At the plateau, the rate of drug elimination is equal to the rate of infusion; thus, the plateau CONCENTRATION is directly proportional to the infusion rate or dose.

d. No fluctuation between doses at the plateau