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18 Cards in this Set
- Front
- Back
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Prednisone, Prednisolone, Cortisol
Class? Mech? Use? Side Effects? |
Class: Glucocorticoid
Mech: Interfere with cell cycle activation in lymphoid cells, Inhibit production of inflammatory cytokines(PAF, leukotrienes, prostaglandins, histamine, bradykinin) Use:immunsuppresive therapy for solid organ xplant. organ rejection or GVHD, rheumatoid arthritis, Inflammatory Bowl Disease(Crohn's) Side Effects: Protein Breakdown, hyperglycemia, avascular necrosis of bone, osteoporosis,(loss of Ca2+) Cushing's-moon face, myopathy, HTN |
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Cyclosporine
Class? Mech? Use? Side Effects? |
Class: Calcineurin Inhibitor
Mech: Binds cyclophilin and inh. calcineurin, inh IL-1, IL-2 prodxn, inh. T cell activation, Metabolized by CYP3A Use:organ xplantation, GVHD autoimmune disorders Side Effects: nephrotoxicity, HTN, Hyperlipidemia, hyperglycemia Watch for: drugs that inh. CYP3A-causes prolonged effects Interaxns: Syngerstic nephrotoxicity with tacrolimus |
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Tacrolimus
Class? Mech? Use? Side Effects? |
Class:Calcinurin Inhibitor
Mech: Binds FKBP-12 which inh. Calcineurin and T celll activation, Metabolized by CYP3A Use: organ xplantation, GVHD Side Effects:nephrotoxicity, hyperglycemia, diabetes, neurotoxicity, Interaxns: Syngerstic nephrotoxicity with cyclosporine, also interact with drugs affecting CYP3A |
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Sirolimus
Class? Mech? Use? Side Effects? |
Class:Antiproliferative and Antimetabolic drugs
Mech: Binds FKBP-12 and inhibits protien kinase mTOR involved in cell cycle progression G1-S, metabolized by CYP3A4 Use: prevention of organ xplant rejection, with combo therapy Side effects: hyperlipidemia, bone marrow suppression, Interaxn: with cyclosporine increases hyperlipidemia |
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Mycophenolate Mofetil
Class? Mech? Use? Side Effects? |
Class: Antiproliferative and Antimetabolic Drugs
Mech: inh. inosine monophosphate dehydrogenase-inhibitin guanine nucleotide synthesis thereby inhibiting lymphocyte proliferation Use:prevent organ xplant rejection in combo with glucocorticoids or Calcineuring Inh. Side effects: Bone marrow suppression, GI disturbances |
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Azathioprine
Class? Mech? Use? Side Effects? |
Class:Antiproliferative and Antimetabolic Drugs
Mech: metabolized in a fraudulent nucleotide and when incorporated into DNA prevents gene xlation and cell proliferation Use:prevent organ xplant rejection, rheumatoid arthritis,remission of Crohns and ulcerative colitis Side Effects: bone marrow suppression, hepatic toxicity |
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Methotrexate
Class? Mech? Use? Side Effects? |
Class Antiproliferative and Antimetabolic Drug
Mech: Folic Acid antagonist-inhibits dihydrofolate reductase(inh. purine nucleotide synthesis), inh. cell proliferation at high doses Use: high doses for chemotherapy, induce remission for Crohn's, rheumatoid arthritis, GVHD Side Effects: bone marrow depression, hepatic damage |
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Cyclophosphamide
Class? Mech? Use? Side Effects? |
Class:Antiproliferative and Antimetabolic Drug
Mech: Alkylating agent-crosslinks DNA leading to cytotoxicity, loss of proliferating lymphoid cells- suppresses T and B cell fxn by 30-40%, must be metabolized by CYP2B into active metabolites Use:Cancer Chemo, organ rejection AFTER xplantation, autoimmune disorders, does not prevent GVHD Side Effects: dose related toxicity of rapidly growing tissues, nausea, vomiting |
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Antithymocyte Globulin
Class? Mech? Use? Side Effects? |
Class: Polyclonal Atb
Mech:Atbs that recognize many surface prot on T cells- binding causes complement activation and cell mediated cytoxicity, blocks lymphocyte prodxn Use:INDUCTION of immunosuppression-T cell count drops by day 2, to treat ACUTE renal xplant rejection Side Effects:fever and chills |
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Rho(D) Immune Globulin
Class? Mech? Use? Side Effects? |
Class: Polyclonal Atb
Mechrecognize Rh(D) atg on RBC- binding prevents sensitization of Rh-neg women to Rh-pos fetus Use: Treat Rh incompatibility and prevent hemolytic disease of newborn Side Effects:fever, |
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Muromondab-CD3
Class? Mech? Use? Side Effects? |
Class:Monoclonal Atb(murine)
Mech:recognizes human CD3- binding inactivates T cell fxn, rapid depletion of T cell, cytokine release Use: Tx of acute allograft rejection and steroid resistant rejection Side Effects: cytokine release syndrome, HAMA rxn |
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Basiliximab, Daclizumab
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb( chimeric)
Mech: recognizes CD25(IL-2 R)-Il-2 antagonist, blocks IL-2 binding of activated lymphocytes, prevents IL-2 mediated T cell activation and proliferation, depletion of activated T cells Use: prevents acute organ rejection Side Effects: GI disturbances |
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Alefacept
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mech: recognizes CD 2, Inhibits T cell activation by binding CD 2 Use: plaque psoriasis Side Effects: reduction of circulating T cells |
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Entanercept
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mech:binds TNF alpha and TNF beta and blocks their binding to their R and leads to suppression of inflammatory cytokines and cell adhesion molecules Use:rheumatoid arthritis Side Effects? |
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Adalimumab, Golimumab
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mechhuman Atb that recognizes TNF alpha, blocks TNF alpha binding leading to suppression of inflammatory cytokines and adhesion molecules Use:rheumatoid arthritis Side Effects? |
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Infliximab Certolizumab
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mech: Recognize TNF alpha, blocks TNF alpha binding to R, suppression of inflammatory cytokines and adhesion molecules Use: rheumatoid arthritis and Crohn's Side Effects? |
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Alemtuzumab
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mech:recognizes CD 52 on normal and malignant T and B lymphocytes, NK cells, monocytes, macros, some granulocytes-depletes leukemic and normal cells by atb-dependent lysis Use: B cell chronic lymphocytic leukemia Side Effects: hematologic toxicity, infxn |
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Rituximab
Class? Mech? Use? Side Effects? |
Class: Monoclonal Atb
Mech: Recognizes CD20-complement mediated lysis, atb-mediated cellular toxicity, induction of apoptosis in malignant lymphoma cells Use: In relapsed of refractory low grade of follicular B cell non-Hodgkin's lymphoma Side Effects? |
