Pharmacology_2 07: Anxiolytics

Front 1

BDZs have both ___ and ___ activity

Back 1

anxiolytic
hypnotic

Front 2

zolpidem acts similarly to ___ but only has ___ activity

Back 2

BDZs
hypnotic

Front 3

buspirone is a ___ agonist with ___ activity

Back 3

5HT1A
anxiolytic

Front 4

beta antagonists reduce ___

Back 4

physical symptoms of anxiety

Front 5

barbiturates are now used for ___ (2)

Back 5

anesthesia
epilepsy tx

Front 6

___, e.g. ___ are sometimes used as sleeping pills

Back 6

sedative antihistamines
diphenhydramine

Front 7

BDZs are well/poorly absorbed from GIT
peak plasma concentration is ___ (time)

Back 7

well
1h

Front 8

BDZs bind strongly to ___s, and accumulate in ___.

Back 8

plasma protein
fat

Front 9

T/F: BDZs can be given IVly

Back 9

true

Front 10

BDZs are excreted by ___ as ___s

Back 10

kidney
glucuronide conjugate

Front 11

short-acting BDZs act for ___ h

Back 11

<6

Front 12

medium-acting BDZs act for ___ h

Back 12

6--24

Front 13

long-acting BDZs act for ___ h

Back 13

>24

Front 14

BDZs should only be used for up to ___ weeks

Back 14

4

Front 15

3 short-acting BDZ

Back 15

triazolam
oxazepam
midazolam

Front 16

4 medium acting BDZs

Back 16

lorazepam
estazepam
temazepam
alprazolam

Front 17

2 medium acting BDZs

Back 17

alprazolam
nitrazepam

Front 18

4 long-acting BDZs

Back 18

diazepam
chlordiazepoxide
flurazepam
clonazepam

Front 19

lorazepam is aka ___
alprazolam is aka ___
diazepam is aka ___
clonazepam is aka ___

Back 19

ativan
xanax
valium
klonopin

Front 20

diazepam is metabolized to ___. ___ is the active molecule

Back 20

nordazepam
nordazepam

Front 21

BDZs act on ___R.
they increase the receptor's ___

Back 21

GABA_A
frequency of opening

Front 22

BDZs cause ___ amnesia

Back 22

anterograde

Front 23

all BDZs cause ___ effect

Back 23

anxiolytic

Front 24

the only BDZ with antidepressant effect is ___

Back 24

alprazolam

Front 25

T/F: BDZs can cause irritability and aggression

Back 25

true

Front 26

BDZs cause mild/severe reduction in REM sleep

Back 26

mild

Front 27

___ is a BDZ used for epilepsy
___ is given IVly for status epilepticus

Back 27

clonazepam
diazepam

Front 28

2 side effects from overdose

Back 28

prolonged sleep
respiratory depression when combined with alcohol

Front 29

___ is a major problem with BDZs
___ is not.

Back 29

dependence
addiction

Front 30

___ is a competitive inhibitor of BDZ

Back 30

flumazenil

Front 31

flumazenil lasts for ___h

Back 31

2

Front 32

T/F: you can give flumazenil in case of suspected BDZ overdose even without proof from blood test

Back 32

true

Front 33

___ glaucoma is a BDZ contraindication

Back 33

acute closed-angle

Front 34

4 other diseases which are BDZ contraindications

Back 34

psychosis
pregnancy
cirrhosis
MG

Front 35

it takes ___ before buspirone takes effect

Back 35

weeks

Front 36

buspirone side effects are better/worse than BDZs

Back 36

better

Front 37

T/F: ondansetron has anxiolytic effect in animals

Back 37

true

Front 38

barbiturates bind to same/different site on GABA_A R
they increase ___ of GABA_AR

Back 38

different
opening time

Front 39

in large doses barbiturates can cause ___ from ___

Back 39

death
respiratory depression

Front 40

barbiturates cause ___ by ___ing.
this can cause ___.

Back 40

dependence
inducing CYP450
bad drug interactions

Front 41

___ is a barbiturate sometimes used for epilepsy

Back 41

phenobarbital

Front 42

2 motor symptoms of barbiturate intoxication

Back 42

loss of coordination
ataxia

Front 43

___ is a hypnotic

Back 43

chloral hydrate

Front 44

ondansetron is a ___ antagonist
it is indicated for ___

Back 44

5-HT3R
anti-emesis