Pharmacology_2 05: Antidepressants

Front 1

lifetime incidence of depression

Back 1

10%

Front 2

depression is believed to be associated with reduced ___ (2)

Back 2

serotonin
NE

Front 3

___ diet caused depressive attack in patients under remission

Back 3

tryptophan free

Front 4

___ blocks VMAT and is associated with increased incidence of depression. it causes depletion of ___ (2)

Back 4

reserpine
5-HT
NE

Front 5

iproniazid is a ___ formerly used for ___

Back 5

MAO inhibitor
TB

Front 6

imipramine is a ___ and blocks ___

Back 6

tricyclic
5-HT reuptake

Front 7

MAO A degrades ___ (4)

Back 7

E
NE
5-HT
DA

Front 8

MAO B degrades ___ (3)

Back 8

phenylethylamine
benzylamine
DA

Front 9

MAO A is present in ___ (3)

Back 9

sympathetic neurons
GIT
5-HT neurons (?)

Front 10

MAO B is present in ___ (2)

Back 10

glial cells
platelets

Front 11

MAO is located in ___ (organelle)

Back 11

mitochondria

Front 12

the MAO you need to inhibit for antidepressent effect is ___

Back 12

A

Front 13

side effect assocated with MAOAIs

Back 13

cheese effect

Front 14

___ is an irreversible MAOI
___ is a reversible one

Back 14

tranylcypromine
moclobemide

Front 15

___ (3) work on both MAO A and B
___ works on A

Back 15

phenelzine
tranylcypromine
isocarboxazide
moclobemide

Front 16

tricyclics elevate effects of ___s like ___, and inhibit the effects of ___ like ___

Back 16

direct-acting sympathomimetic amines
E
indirectly-acting amines
tyramine

Front 17

tricyclics have anti-___ (2) effects

Back 17

cholinergic
alpha1

Front 18

2 anticholinergic side effects

Back 18

dry mouth
blurry vision

Front 19

anti-alpha1 side effect

Back 19

hypotension

Front 20

tricyclic overdose can cause cardiac ___ (2)

Back 20

arrhythmia
negative inotropism

Front 21

secondary amine tricyclics work on ___, tertiary amines work on ___ (2)

Back 21

NE
NE
serotonin

Front 22

3 tertiary amine tricyclics

Back 22

imipramine
amitryptiline
clomipramine

Front 23

3 secondary amine tricyclics

Back 23

desiprimine
nortryptiline
maprotiline

Front 24

___ is a tetracyclic which is highly ___ selective

Back 24

maprotiline
NE

Front 25

___ is the paradigmatic SSRI

Back 25

fluoxetine

Front 26

___ usually increases libido and ___ decreases it

Back 26

DA
serotonin

Front 27

SSRIs act mostly on ___ (anatomical location), where ___ is produced

Back 27

raphe nuclei
serotonin

Front 28

prolonged administration of antidepressants causes downregulation of ___

Back 28

CNS beta adrenoreceptors

Front 29

SNRIs are ___.
1 example is ___.

Back 29

serotonin and NE reuptake inhibitors
venlafaxine

Front 30

SSRIs block

Back 30

5-HTT

Front 31

mirtazipine blocks ___ (3) receptors

Back 31

alpha2
5-HT2
5-HT3

Front 32

Li mechanism

Back 32

blocks conversion of inositol-phosphate to inositol

Front 33

5 Li side effects

Back 33

thyroid hyper/hypo
renal DT hypofunction
tremor
edema
negative chronotropy

Front 34

nefazodone mechanism

Back 34

5-HTT blockade
5-HT2 antagonism

Front 35

nefadozone is ___toxic

Back 35

hepato

Front 36

tricyclics can initially cause ___, but as a side effect cause reduced ___

Back 36

sedation
REM sleep

Front 37

SSRI side effects (2)

Back 37

appetite suppression
libido suppression

Front 38

there is a therapeutic lag for SSRIs to work because ___ needs to happen

Back 38

5HT1AR downregulation

Front 39

mirtazipine blocks ___ (3)

Back 39

alpha2R
5HT2AR
5HT3R

Front 40

ipsapirone blocks ___

Back 40

5HT1AR

Front 41

prolonged adminstration of all antidepressants except ___ causes downregulation of ___

Back 41

fluoxetine
CNS beta-adrenoceptors

Front 42

beta-adrenoceptor downregulation happens after phosphorylation by ___ (2). ___s then cause internalization.

Back 42

PKA
GRK
beta arrestin

Front 43

antidepressant effect is associated with ___

Back 43

neurogenesis

Front 44

secondary/tertiary amine tricyclics have more anticholinergic side effects

Back 44

tertiary

Front 45

___ is the least sedating TCA

Back 45

desipramine

Front 46

desimpramine raises/lowers seizure threshold

Back 46

lowers

Front 47

because ___, nortryptiline is the TCA of choice for elderly patients

Back 47

anticholinergic effects cause confusion

Front 48

3 C's of TCA toxicity

Back 48

convulsion
coma
cardiotoxicity

Front 49

cardiac problem caused by TCAs

Back 49

arrhythmia

Front 50

cardiotoxicity of TCAs is similar to that of ___
it affects phase ___ of cardiac AP by ___ing

Back 50

quinine
0
blocking Na+ current

Front 51

TCA cinchonism is treated with ___

Back 51

sodium bicarb

Front 52

TCAs also cause ___ depression and hyper___

Back 52

respiratory
pyrexia

Front 53

tx for serotonin syndrome
mechanism is ___

Back 53

cyproheptadine
5-HT2R block

Front 54

2 SNRIs
___ has greater NE effect

Back 54

duloxetine
venlafaxine
duloxetine

Front 55

venlafaxine is indicated for ___ (2)

Back 55

depression
generalized anxiety disorder

Front 56

duloxetine is indicated for ___ (2)

Back 56

depression
neuropathic pain

Front 57

most common SNRI toxicity effect

Back 57

HTN

Front 58

MAOIs can't be given with ___ or ___ because of ___

Back 58

SSRIs
meperidine
serotonin syndrome

Front 59

3 specific MAOI indications

Back 59

atypical depression
anxiety
hypochondriasis

Front 60

buproprion works on ___ (2 neurotransmitters)
it has high/low sexual side effects

Back 60

NE
DA
low

Front 61

buproprion toxicity causes ___,
but mirtazapine toxicity causes ___.

Back 61

stiumlation
sedation

Front 62

maprotiline mechanism is ___
toxicity causes ___

Back 62

NE reuptake block
sedation

Front 63

trazodone is indicated for depression with ___.
it works primarily by ___ing.

Back 63

insomnia
blocking 5-HTRs

Front 64

trazodone toxicity causes ___ (3)

Back 64

priapism
sedation
nausea