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42 Cards in this Set

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Epinephrine
alpha & beta Adrenergic agonist

MOA: beta-2 agonist --> increased cAMP -->immediate relaxation of bronchial smooth muscle cells-->bronchodilation
Albuterol/Ventolin, Proventil
Salmeterol/Serevent
beta-2 agonist
(Salmeterol long acting beta-2 agonist)

MOA: Bronchodilation via --> beta-2-adrenergic receptor stimulation-->increased cAMP levels-->bronchial smooth muscle relaxation
Beclomethasone/beclovent
corticosteroid

MOA: decreased inflammation & edema in respiratory tract via reduction in # & activity of møs, eos, t-lymphs, decreased permeability of capillaries, inhibited release of leukotrienes
Cromolyn/Intal
mast cell inhibitor

MOA: prevents release of inflammatory mediators (histamine) from mast cells, møs, neuts, eos
Zafirlukast/Accolate
Leukotriene receptor antagonist

MOA: competitive antagonism of leukotriene D4 & E4 receptors--> inhibits bronchoconstriction
Prednisone/Deltasone
corticosteroid

MOA: decrease inflammation & edema in respiratory tract
Diphenyhydramine/Benadryl
sedating antihistamine

MOA: H1 receptor blocker

the production and release of histamine is not blocked!
Loratadine/Claritin
non-sedating antihistimine

MOA: H1 receptor antagonist
Codeine
antitussive, narcotic analgesic and cough suppressant

MOA: suppresses the sensitivity of CNS cough centers
Dextromethorphan
antitussive, synthetic derivative of codeine analog

MOA: suppresses the sensitivity of CNS cough centers
Morphine sulfate/MS Contin
narcotic analgesic

MOA: opiod agonist, raise pain threshold at spinal cord level, alter brain's perception of pain
Fentanyl/Duragesic
narcotic analgesic

MOA: similar to morphine w/80x the analgesic property of morphine
Codeine
analgesic

MOA: opiod agonist, weaker than morphine
Naloxone/Narcan
narcotic antagonist

MOA: bind with high affinity to opiod receptors but fail to activate the receptor mediated response
Aspirin
NSAID analgesic
MOA: irreversible inhibition of COX-1 & COX-2 enzymes. anti-inflamm & analgesic effects dt blockade of prostaglandin synthesis at target tissues. anti-pyretic effect dt blockade at thermoregulatory centers in HTH. PGE2 sensitizes nerve endings to actions of bradykinins, histamines & other inflammatory mediators
Ibuprofen/Motrin, Advil
NSAID analgesic

MOA: reversible inhibition of COX-1 & COX-2 enzymes
effect dt blockade of prostaglandin synthesis at target tissue
Celecoxib/Celebrex
NSAID analgesic

MOA: reversible selective COX-2 inhibition
Acetaminophen/Tylenol
analgesic, antipyretic

MOA: weak peripheral blockade of prostaglandin synthesis
Lidocaine/Xylocaine
amide local anesthetic

MOA: temporary reduciton of nerve membrane permeability to Na+
action potentials cannot be generated or propagated
Benzonatate/Tessalon
ester local anesthetic

MOA: numbing of stretch receptors in the bronchus diminishes cough reflex
Phenobarbitol
sedative hypnotic/barbituate

MOA: binding to barbituate receptors in the CNS-->interruption of Na/K ion exchange = enhanced GABA sensitivity
Diazepam/Valium
anxiolytic/benzodiazepine/sedative hypnotic

MOA: GABA agonist. binds to benzodiazepine receptor--> enhancing GABA activity
Flumazenil
benzodiazepine receptor antagonist

MOA: competitive antagonist
Imipramine/Tofranil
antidepressant

MOA: blocks reuptake of norepinephrine and seratonin
Bupropion/Wellbutrin, Zyban
atypical antidepressant

MOA: inhibits reuptake of norepi, seratonin, and at high doses, dopamine
Isocarboxazid/Marplan
MOAI antidepressant

MOA: inhibits monoamine oxidase
Fluoxetine/Prozac
MOA: SSRI antidepressant
Lithium
antidepressant

MOA: inhibits synthesis of the second messenger IP3
Methylphenidate/Ritalin, Concerta
CNS stimulant

MOA: indirect acting adrenergic agonist increases release of norepi
Levodopa/L-Dopa
Antiparkinsonian

MOA: increases synthesis of dopamine
Bromocriptine/Parlodel
Antiparkinsonian

MOA: dopamine receptor agonist
Selegiline/Eldepryl
Antiparkinsonian

MOA: MAO inhibitor
Benztropine/Congentin
Antiparkinsonian

MOA: muscarinic & histaminic receptor antagonist anti-cholinergic
Amantadine/Symmetrel
Antiparkinsonian

MOA: increased release of dopamine by unknown mechanism
Entacapone/Comtan
Antiparkinsonian

MOA: COMT inhibitor
Donepezil/Aricept
Alzheimers

MOA: Acetylcholinesterase inhibitor
Interferon beta-1b/Betaseron
multiple sclerosis

MOA: immune modulation/biologic response modifier
Clonazepam/Klonapin
benzodiazepine

MOA: anti-seizure MOA unclear
Phenytoin/Dilantin
anticonvulsant

MOA: reduces Na+, Ca+, and K currents across neuronal membranes. unclear as to which effect is responsible for seizure prophylaxis
Primidone/Mysoline
anticonvulsant

MOA: exact MOA unknown, but phenobarbitol is a metabolite of primidone
Carbamazepine/Tegretol
anticonvulsant

MOA: similar to phenytoin in the reduction of Na+, Ca+ & K currents across neuronal membranes
Valproic acid/Depakote
anticonvulsant

MOA: unknown, enhancement of GABA transmission has been postulated