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9 Cards in this Set

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This is one of the most important risk factors for the developmemt of CHD.
LDL
How is cholesterol used in the body?
- structure of cell membrane
- synthesis of certain hormones (testosterone, estrogen, progesterone, adrenal corticosteriods - glucocorticoids,mineralcorticoids )
- synthesis of bile salts - components of bile
- synthesis of
What is an important enzyme for synthesis of cholesterol?
HMG - coenzyme A reductase

hydroxy- methyl glutaryl
high cholesterol aka

=
hypercholesterolemia = elevated SERUM levels of cholesterol
primary vs secondary hypercholesterolemia
primary - genetic

secondary - diet, disease, medication
What are secondary factors for development of dyslipidemia?
diet - intake of sat fats

disease - DM, obesity, obstructive liver disease?, alcoholism, hypothyroidism

Medications - beta-blockers, thiazide diuretics, cyclosporins, ..oral estrogens, glucocorticoids
Would ingesting cholesterol or saturated fats increase serum cholesterol?
ingesting cholesterol increases it a little, but there is a compensatory mechanism in which the body limits cholesterol production

ingesting sat. fats increases chol levels much more
What is normal levels for serum triglycerides?
100-200mg/dl
At what levels should you maintain your cholesterol? LDL and HDL?

what is considered high?
total cholesterol should stay < 200mg/dl. High > 240.

LDL stay < 100. High >160.

HDL is better if higher. <40 is low.