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21 Cards in this Set

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What is somatrem used for and what is its mech. of action?
it is an analog of somatotropin and it is used to treat pituitary dwarfism and osteoporosis (used when you need more growth hormone)
What is leuprotide and how is it used?
it is an analog of GnRH. thus if it is given in a pulsitile fashion (physiologically) it will increase LH and FSH....but more importantly, if it is given in a repository form (large amount at one time) it will have the opposite effect and it will decresae LH and FSH secretion
What is the drug urofollitin?
it is FSH taken from the urine of postmenopausal women, and used in conjunction with hCG to induce ovulation
What is octreotide used to treat and what is the mech of action?
it is an analog of somatostatin and it is used to treat acromegaly, and carcinoid or secretory GI tumors (used when you need somatostatin to inhibit secretions)
What is placental HCG?
The is very similar to LH and can be used along with urofollitin (FSH) to induce ovulation
What is somatropin used to treat and what is the mech of action?
it is an analog of somatotropin and it is used to treat pituitary dwarfism and osteoporosis. (used when you need more growth hormone)
What is naferelin and how is it used?
it is an analog of GnRH. thus if it is given in a pulsitile fashion (physiologically) it will increase LH and FSH....but more importantly, if it is given in a repository form (large amount at one time) it will have the opposite effect and it will decresae LH and FSH secretion
What is the treatment for hyperprolactinemia and what is the mechanism
Pergolide or bromocriptine both activate the dopamine receptor i nthe Anterior pituitary to inhibit the relase of prolactin
What does oxytocin as a drug do?
labor induction and milk let down
What is desmopressin used for?
it is V2 receptor selective form of vesopressin and thus is used for neurogenic diabetes insipitus.....it is also used i nhemophilia A because it increases factor VIII from the liver and it is used in von Willebrand disease because it increases vW factor form endothelium
What are the two main thioamides?
propylthiouracil and methimazole
What are the actions of thioamides?
-Decrease iolination of tyrosyl residues on thyroglobulin and cecrease coupling reactions forming DIT, T3 and T4
What does high doses of iodide do?
Decreases coupling reactions forming DIT, T3, and T4......Decreases proteolytic relase of T4 and T3 from thyroglobulin and decreases size, vascularity and fragility of thyroid gland (and thus is widely used presurgically)
What does high dose ipodate do?
decreases proteolytic release of thyroid hormones
What does a regular does of ipodate do?
blocks the 5'deiodinase and thus blocks convertsion of T4 to T3.
What other drugs besies ipodate block 5' deiodinase?
propranolol and a high dose of propylthiouracyl
What is the onset of propylthiouracyl (PTU) and methimazole?
slow and thus is used for uncomplicated hyperthyroidism
What are the adverse effects of propylthiouracyl and methimazole?
common maculopapular rash and less common decrased prothrombin, hypersensitivity, arthralgia, jaundice, and vasculitis
Which thioamide is safer in pregnancy?
PTU is safer in pregnancy because it is extensively bound to protein
What is KI plus iodine known as and what is it given form?
it is "Lugol's solution" and it is given for thyrotoxicosis
How long can iodide treatment be used?
not long term because thyroid gland "escapes" it's effects