Pharmacology Unit 4

Front 1

A drug is any substance that is taken to:

Back 1

Prevent
Cure
Reduce
Symptoms of a medical condition

Front 2

What is the name of the drug given to the pharmaceutical company marketing the drug:

Back 2

Brand Name

Front 3

Term used for the role and extent in which the active ingredient are absorbed from a drug product and then available at the site of action

Back 3

Bioavailability

Front 4

Act that states narcotics are used appropriately, not prescribed to addicts, and is illegal to possess w/o a prescription

Back 4

Harrison Narcotic Act 1912

Front 5

Act that broke drugs into schedules (narcotics)

Back 5

Comprehensive Drug Abuse Prevention and Control Act 1970

Front 6

Act that states drugs must be tested thoroughly (FDA has power to recall)

Back 6

Food, Drug, and Cosmetic Act 1938

Front 7

Act that States drug saftey and effectiveness had to be established

Back 7

Kefauver-Harris Amendment 1962

Front 8

Act that gives financial incentives to companies to produce drugs that are not in high demand:

Back 8

Orphan Drug Act 1983

Front 9

FDA responsibilities?

Back 9

Drug Saftey
Withdraw Drug
Oversee drug research process

Front 10

FDA stage where drugs are tested on animals:

Back 10

Preclinical-Laboratory

Front 11

FDA stage where there are usually 20-80 healthy young male volunteers

Back 11

Phase I

Front 12

In phase one, the drug is dropped if:

Back 12

No effect
ADR (toxic)

Front 13

FDA stage where the drug is offered to poeple who have the disease (several hundred clients)

Back 13

Phase II

Front 14

FDA stage where study is turned to public and the trials are led by MD's and nursing researchers

Back 14

Phase III

Front 15

FDA stage where post marketing surveillance is taken place:

Back 15

Phase IV

Front 16

What phase is a placebo used in:

Back 16

Phase II

Front 17

Why is a placebo used:

Back 17

To compare drug actions and adverse effects

Front 18

What is a negative effect have having the approval time cut in half?

Back 18

Harm to people

Front 19

What kind of drugs may become addictive:

Back 19

Prescription Drugs

Front 20

What is the term used for when a prescription drug can be changed to OTC

Back 20

Reclassification

Front 21

Type of drug that is not regulated as stringently as drugs by the FDA
(can impair or enhance Coumadin)

Back 21

Supplements

Front 22

Coumadin is used to prevent:

Back 22

Blood clots

Front 23

The two schedule drug classes that are at high potential for abuse:

Back 23

I and II

Front 24

What are some schedule I drugs:

Back 24

Extacy
LSD
Heroin
Marijuana

Front 25

What are some schedule II drugs:

Back 25

Morphine
Oxycodone

Front 26

What schedule drug class is at a little less for potential for abuse:

Back 26

III

Front 27

Waht is a Schedule III example:

Back 27

Hydrocodone

Front 28

How is schedule IV and V drugs classified:

Back 28

Low Potential for Abuse

Front 29

What are some schedule IV examples:

Back 29

Benzodiazapm
Sedatives
Hypnotics

Front 30

What is a common term in a drug name that "treats the problem"

Back 30

-lytic

Front 31

Anxiolytics does what:

Back 31

Stops anxiety

Front 32

What is an example for V drug:

Back 32

Cough syrup with codeine

Front 33

Term used for what a drug does to the body:

Back 33

Pharmocakinetics

Front 34

What are the factors affecting absorption:

Back 34

Blood flow to absorption site
Acids absorbed in acid (stomach)
Bases absorbed in base(intestine)

Front 35

Where is the primary site of absorption:

Back 35

Small Intestine

Front 36

What kind of surgery will cause malabsorption

Back 36

Gastric Bypass

Front 37

What is a risk associated with increased free drug:

Back 37

Increased risk for toxicity

Front 38

An increased protein bound drug will bind to :

Back 38

Proteins foods

Front 39

When a protein bound drug binds to foods what happens to the effect of that drug:

Back 39

Decreases

Front 40

Where is the drug metabolized:

Back 40

Liver

Front 41

What will cause impaired drug metabolism:

Back 41

liver dysfunction

Front 42

An increased of free drug in the body is an indication of:

Back 42

Liver Dysfunction

Front 43

Term used for when the drug is dissolved then partially circulated and metabolized before distributed:

Back 43

First Pass Effect

Front 44

What are factors that affect meatbolism:

Back 44

Young/Old
Liver Impairment
CYP Enzymes

Front 45

what would you do to the dose with a person with renal dysfunction

Back 45

decrease

Front 46

what do you do when a drug has a narrow margin of saftey?

Back 46

monitor blood levels

Front 47

Wehn does a drug begin to work?

Back 47

Onset

Front 48

When is a drug most effective

Back 48

peak

Front 49

how long does a drug last

Back 49

duration

Front 50

What is an unusual or unexpected response?

Back 50

Idiosyncratic Response
(gentic makeup)

Front 51

What controls access to brain:

Back 51

Blood brain barrier

Front 52

The sum of the 2 chemicals taken together is equal to the sum of the 2 chemicals taken separately

Back 52

Additive

Front 53

The sum of the 2 chemicals taken together exceeds the sum of the drugs taken seperately

Back 53

Synergistic