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11 Cards in this Set
- Front
- Back
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nicotine
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directly activates nicotinic ACh receptors centrally, peripherallly and at NM junction
centrally produces strong dependence |
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Nicotine Replacement
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Reduces nicotine withdrawal and craving
Contains 1/3 to 1/2 the nicotine No tar, carbon monoxide orother chemicals used together with combination cessation program |
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OTC nicotine replacement products
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Nicorette (gum)
Nicotine lozenges nicotine Patch (Nicoderm CQ) |
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Prescription Nicotine Replacement products
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nicotine oral inhaler (Nicotrol Inhaler)
Nicotine nasal inhaler (Nicotrol NS) |
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Nicotine Gum
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dont chew (keep between cheek and gums)
SE: tingling, hiccups, jaw pain , nausea, heartburn |
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Nicotine Lozenge
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do not swallow
SE: headache, flatulence, hiccups, heartburn/nausea |
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Nicotine patch
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dose based on # of cigarettes per day
SE: skin rash, sleep disturbances |
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nicotine inhaler
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SE: cough, scratchy throat, GI upset
avoid in asthma patients |
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Bupropion (zyban)
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MOA unknown
Quit rate - 23-33% Adding nicotine replacement products improves chances AE: difficulty sleeping, difficulty concentrating , tremor, GI upset |
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Varenicline (Chantix)
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agonist at a sub-type of the nicotinic ACh receptor
Prevents nicotine from binding to these receptors which are responsible for reinforcement and reward experienced from smoking AE: nauseam headache, insomina, abnormal dreams |
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Black Box for Bupropion and Varenicline
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Serious neuropsychiatric events
Depression, suicidal ideation, suicide attempts, completed suicides Changes in behavior – aggression, hostility, agitation Weigh risks vs. benefits |
