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7 Cards in this Set
- Front
- Back
Levothyroxine T4, Liothyronine T3
1. MOA 2. Use 3. Tox 4. Which is preferred? |
1. Nuclear receptors respond with gene expression and protein synthesis
2. Replace Thyroid hormones T3 and T4 in HYPOTHYROIDISM 3. Symptoms of Thyroid Excess Low TI --> Arrhythmia, MI 4. Levothyroxine T4 --> Log time for steady state, but less frequent dosing |
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Thioamides - Propylthiouracil (PTU), Methimazole
1. MOA 2. Use 3. Tox 4. Which is preferred in pregnancy? |
1. Inhibit Thyroid Peroxidase
Inhibit Iodine organification Inhibit peripheral conversion of T4 to T3 2. Hyperthyroid - Decrease synthesis of Thyroid hormone 3. N/V, rash, Agranulocytosis, Hepatitis, Hypothyroid 4. PTU |
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Iodides - Lugol's solution, KI
1. MOA 2. Use 3. Tox 4. When is it used for Thyroid Storm? |
1. Block thyroid hormone release - By blocking the Na+/I- pump (clogs it)
Reduce size of gland 2. Decrease gland size prior to Thyroidectomy Radiation Accident 3. Metal taste, Rash, fever 4. After Methimazole or PTU is used to lock down peroxidase |
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Radioactive Iodine (131I)
1. MOA 2. Use 3. Tox |
1. Thyroid gland ablation
2. Treat hyperthyroidism 3. Sore throat, Hypothyroid |
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Beta Blockers (propranolol)
1. MOA 2. Use 3. Tox |
1. Non-selsctive Beta Blockade
2. Protect against ventricular tachycardia and arrhythmias during thyroid storm 3. Asthma, Hypoglycemia, AV Block, Hypotension, bradycardia |
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Perchrlorate, Thiocyanate
1. MOA 2. Use 3. Tox |
1. Anion inhibitors
2. Block uptake of Iodide by the Thyroid gland 3. Aplastic anemia |
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1. What do you use for Thyrotoxicosis, Primary Hyperthyroidism?
2. What would you do for Secondary Hyperthyroidism? |
1. Methimazole or PTU
2. Refer to endocrinologist |