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28 Cards in this Set
- Front
- Back
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Mechanism of tetracylcines
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bind to 30s bacterial ribosomal RNA, and inhibit protein synthesis
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structure of tetracycline
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four 6 membered rings fused together
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Tetracycline: bacteriocidal or bacteriostatic?
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bacteriostatic
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What bacteria does tetracycline work on?
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aerobic and anaerobic gm (+) and gm (-) bacteria
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What is the most widely prescribed tetracycline
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doxycycline
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What's first line for Rickettsia?
Second line? |
1: doxycycline
2. chloremphinicol |
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What is doxycline first line for?
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cholera (vibrio cholerae), brucellosis (brucella), chlamydia pneumoniae, ricketsia
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Which drug treats carrier state of meningitis (neisseria mening)
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minocycline (dynacin, minocin)
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Which tetracycline can treat MRSA, MRSE, VISA, VRSA, PCN-resistant strep pneum, VRE?
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Tigecycline
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TQ: What is the most common ode of resistance for tetracyclines?
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decreased accumulation due to increased efflux by an active transport protein pump that leads to failure of the microorganism to accumulate the antibiotic
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TQ: Which tetracyclines are safe to give to pts with
1. renal failure 2. reduced renal function |
1. doxycycline
2. tigecycline |
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Tetracyclines are contraindicated in ...?
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pregnant females, breast feeding, kids less than 8 y.o
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what drugs can be given for Prophylaxis of endocarditis?
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1. amoxicillin
2. cefazolin back ups if allergic to b-lactam: 2. clindamycin |
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which drugs are photosensitive?
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tetracycline and floroquinolones
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What drugs cause Fanconi syndrome when outdated and degraded?
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tetracyclines
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which drug causes fetal teeth and fetal bone formation, brown discoloration of teeth?
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tetracyclines
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Side effects of minocycline
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vestibular problems and pseudotumor cerebri (increased intracranial pressure and blurred vision and headache)
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TQ: adverse effects of aminoglycosides?
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ototoxicity and nephrotoxicity and neuromuscular paralysis (think boxer)
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are aminoglycosides absorbed folowing oral administration
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no
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mechanism of action of aminoglycosides
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interacts w 30s ribosomal subunit, inhibting bacterial protein sythesis
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what are aminoglycosides commonly synergistic with
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b-lactams
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which drug has post-antibiotic effect
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aminoglycosides
- their killing action continues w/ residual bactericidal activity when their serum leves have declined |
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are aminoglycosides active against aerobic or anaerobic?
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only aerobic
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Which aminoglycosides could be used against MRSA
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gentamicin and tobramycin
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which aminoglycoside is first line for pseudomonas aeruginosa
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tobramycin
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Which aminoglycosides are not used systemically
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neomycin and kanamycin
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Which drug can cause permanent deafness?
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aminoglycosides
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TQ: what are the main adverse effects of tetracyclines?
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ototoxicity and nephrotoxicity and neuromuscular paralysis
(think of the boxer) |
