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14 Cards in this Set

  • Front
  • Back
beta agonist: terbutaline, albuterol, salmeterol

muscarinic antagonists: ipratropium

methylxanthines: theophylline
anti-inflammatory agents
corticosteroids: beclomethasone, fluticasone, budesonide, prednisone.

leukotriene pathway modifiers: zileuton, zafirlukast, montelukast

release inhibitors: cromolyn, nedocromil

anti-IgE therapy: omalizumab
beta agonists: short acting: albuterol, terbutaline

long acting: salmeterol
Sympathomimetics: Muscarinic antagonist
slightly less effective than beta agonists. Role in COPD

Ipratropium bromde: selective derivative of atropine
mech: adenosine antagonism, relaxes bronchial SM. PDE inhibition, anti-inflammatory

drug: aminophylline
Issues with aminophylline
intx w/ many drugs

side effects: arousal, tremor, tachycardia

intxn w/ macrolide antibiotics, can lead to theophylline buildup

narrow TI
potentiate beta agonist, anti-inflammatory, reduce bronchial reactivity.
corticosteroids: Mech
inhibit eos, cytokine production, phospholipase A2 thereby inhibiting prostaglandins and leukotriene synthesis
corticosteroid drugs
Inhaled: beclomethasone, fluticasone, budesonide.

Oral: prednisone
adverse effects:
inhaled: cataracts, decrease bone desnity, oral candidiasis

Oral: wt gain, iatrogenic Cushing's, adr suppression
Cromolyn and Nedocromil
Prophylaxis only, no effect on SM

Mech: inhibit Cl channel, reduce Ca in mast cells, inhibit IgE production by B lymphocytes
Leukotriene Pathway Inhibitors
good for aspirin or excercise induced asthma, less effective than corticosteroids. Taken orally.

Mech: inhibit LK synthesis

LTC4 and LTD4 cause bronchoconstriction which are inhibited.
LT drugs
Zileuton: 5 lipoxygenase inhibitor

Zafirlukast and montelukast: CysLT1 receptor antagonist (blocks LTC4 and LTD4, LTE4, LTF4)
anti-IgE antibody, blocks IgE dependant mast cells activation by removing unbound circulating IgE. I.V. or S.C. every 2-4 wks.