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3 Cards in this Set
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Phenytoin
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inhibits Na channel, part of frontline drugs for all seizures.//
NONLINEAR relationship between dose and [plasma], so small increase in dose >> large [plasma] increase.// adverse: gingival hyperplasia, hisutism, coarsed facial features, may interfere with thyroid function test. |
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Phenobarbital
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a barbiturate, modulates GABAa-R and decreases glutamatergic transmission.//
COMMONLY USED IN INFANTS, NOT IN OTHER POPULATIONS.// |
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So what to do with pregnant pts?
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consider either discontinuation prior and during the pregnancy if withdrawal does not posses serious threat to the pt. OR monotherapy with lowest effective dose.//
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