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33 Cards in this Set
- Front
- Back
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Alpha 1
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1.Adrenergic
2.NE, Epi @high 3.BLOOD VESSELS, also in skin, male sex organs, ureters, bronchial glands 4.Gq 5.PLC 6.IP3, DAG, PKC 7.Vasoconstriction 8.Increased HR Increased BP Increased Sympathetic |
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Alpha 2
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Adrenergic
2. Epi 3. PRE-SYNAPTIC NEURON (CNS) (negative feedback) PERIPHERAL VESSELS 4. Gi (inhibitory) 5. AC 6. cAMP 7. Vasodilation 8. Decreased Sympathetic Decreased HR Decreased BP |
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Beta 1
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Adrenergic
2. NE, Epi 3. HEART, Kidneys 4. Gs 5. AC 6. cAMP 7. Contraction 8. Increased HR |
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Beta 2
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Adrenergic
2. Epi 3. LUNGS, Smooth muscle 4. Gs 5. AC 6. cAMP 7. Vasodilation 8. Decreased TPR |
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M1, M5(CNS)
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Muscarinic
2. ACh 3. M1: Enteric Nervous System, Neuron Ganglia 4. Gq 5. PLC 6. IP3, DAG 7. Vasoconstriction 8. Increased cognitive function Increased seizure activity Increased motility, tone |
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M2, M4(CNS)
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Muscarinic
2. ACh 3. M2: HEART, Smooth muscle (GI sphincter), Nerves 4. Gi (inhibitory) 5. AC (inhibition) 6. Decrease in cAMP 7. Activate K+ channels, Suppress Ca2+ channels 8. Decrease HR (SA node) Decrease Contractility Decrease Conduction velocity |
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M3
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Muscarinic
2. ACh 3. SMOOTH MUSCLE (GUT), Glands, Endothelia (non-innervated) 4. Gq 5. PLC 6. IP3, DAG 7. Contraction (GI) during PNS; Vasodilaion (endothelium) 8. Increased Motility Increased Tone in the stomach |
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Nn (neuronal)
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Nicotinic
2. ACh, Nicotine 3. Autonomic Post-Ganglia (For PNS, SNS) 4. Subtypes Alpha, Beta 5. Increase in Na+ 6. AP 7. Increase in Ca2+ 8. Increase in BP |
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Nm (Skeletal)
1.Class 2.NT agonist 3.Location 4.G-Protein 5.Signal Transduction 6.Second Messenger 7.Action 8.Result of Stimulation |
1. Nicotinic
2. ACh 3. Skeletal Neuromuscular Junction 4. Subtypes: Alpha, Beta, Gamma, Sigma?, Epsilon 5. Increase in Na+ 6. AP 7. Increase in Ca2+ 8. Skeletal Muscle Contraction |
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Alpha 1 Agonists
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1. Phenylephrine
2. Metoxamine |
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Alpha 1 Antagonists
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1. Prazosin (selective antagonist for Alpha 1)
2. Terazosin (selective for A1) 3. Phenoxybenzamine (nonselective for A1 and A2) 4. Phentolamine (nonselective A1, A2) |
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Alpha 2 Agonist
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Clonidine (severe migranes)
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Alpha 2 Antagonist
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1. Yohimbine
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Beta 1 Agonist
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1. Doubutamine
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Beta 1 Antagonists
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1. Atenolol (selective B1)
2. Esmolol (selective B1) 3. Metoprolol (selective B1) 4. Pindolol (non-selective B1, B2 = ISA partial antagonist) |
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Beta 2 Agonists
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1. Terbutaline
2. Albuterol |
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Beta 2 Antagonist
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1. Propranolol (non-selective B1, B2) reversible
2. Pindolol (non-selective B1,B2 partial antagonist) |
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Nn Agonists
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1. ACh
2. Nicotine |
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Nn Antagonists
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1. Trimethaphan
2. Mecamylamine |
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Nm Agonist
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1. Acetylcholine
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Nm antagonists
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1. Tubocurarine
2. Cholinesterase Inhibitor (Neostigmine) |
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Muscarinic agonists
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(also called Parasympathomimetics)
(Direct acting: choline ester) 1. ACh 2. Pilocarpine (PA) ((muscarinic effect only)(Non-Ester and not hydrolyzed ;No Nicotinic effects; Used topically to treat glaucoma; and to treat dry mouth of Sjorenson’s disease 3. Carbachol (muscarinic effect AND ganglionic effect) |
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Muscarinic antagonists
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(Direct acting: Alkaloid)
1. Atropine 2. Scopolamine |
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Direct acting Cholinergic Drugs
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Receptor Agonists
1. Choline esters 2. Alkaloids |
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Indirect acting Cholinergic Drugs
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Cholinesterase Inhibitors
1. Carbamates (reversible) 2. Organophosphates (irreversible) |
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Antidote to Curare overdose
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Neostigmine (carbamate) (Nm antagonist) (reversible with longer duration of action)
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Treatment of Myasthenia Gravis
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Neostigmine (carbamate) (Nm antagonist)
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Antidote to Atropine overdose
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Physostigmine (carbamate) (Nm antagonist)
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Antidote to Organophosphate
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2-PAM
**But first thing to give is Atropine** (musc. antag) |
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NMJ Depolarizing drug
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Succinycholine
paralyzes you used in hospital settings for intubation |
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NMJ Non-Depolarizing Drug
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D-tubocurarine (Curare) = paralyzes you and you die from diaphram paralysis
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Diagnosis of Myasthenia Gravis
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edrophonium (non-depolarizing agent, similar to curare)
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What does NO (nitrous oxide) do?
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Leads to VASODILATION (think about viagra; same effect)
M3+Gq--Ca2+---NOS---Larg--Lcitrine---NO---cGMP---Vasodilation |
