Pharmacology Test #1

Front 1

movement of drug from site of administration into the plasma

Back 1

drug absorption

Front 2

movement of drug from plasma to tissues

Back 2

drug distribution

Front 3

enzymatic alteration of drug (liver)

Back 3

drug metabolism

Front 4

The study of drug disposition in body

Back 4

pharmacokinetics

Front 5

plasma drug concentration dependent on the rates of 3 processes:

Back 5

absorption, distribution, and elimination

Front 6

elimination due to 2 processes:

Back 6

metabolism (biotransformation) and excretion

Front 7

Large number of lipid barriers (membranes) that separate compartments
Most drugs are weak acids or weak bases that exist as charged (water-soluble) or uncharged (lipid-soluble) depending on pH

Back 7

lipid diffusion

Front 8

For passage of most molecules up to 1,000 Daltons MW
Occurs in larger aqueous compartments in the body (interstitial space, cytosol)
Driven by concentration gradient of drug- ‘downhill movement’

Back 8

aqueous diffusion

Front 9

Carrier molecule needed
Energy provided by ATP hydrolysis
Transport against concentration gradient

Back 9

active transport

Front 10

Carrier molecule needed
No energy used
No transport against concentration gradient

Back 10

facilitated diffusion

Front 11

For large substances to enter the cells;
examples: iron and vitamin B12
each complexed with appropriate binding
proteins (transferrin and intrinsic factor)
Liposomal drugs used for cancer treatment

Back 11

endocytosis

Front 12

For an acidic drug: _____ is lipid soluble.

Back 12

protonated

Front 13

For a basic drug: _____ is lipid soluble.

Back 13

unprotonated

Front 14

For salicylic acid, which is a weak acid with a pKa of 3, log [HA]/[A-] is 3 minus the pH. At a pH of 2, then, log [HA]/[A-] = 3 - 2 = 1. Therefore, [HA]/[A-] = 10/1.

Back 14

good example question