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2 Cards in this Set
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- Back
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Mechanisms of movement across biological barriers?
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1) Aqueous Diffusion
*• Occurs in larger aqueous compartments of the body (interstitial space, cytosol, etc) and across epithelial membrane tight junctions and the endothelial lining of blood vessels through aqueous pores that, at some spots, permit the passage of molecules as large as MW 20,000-30,000. • Driven by concentration gradient of permeating drug. • Drugs bound to large plasma proteins (e.g., albumin) will not permeate these aqueous pores. 2) Lipid Diffusion 3) Special Carriers 4) Endocytosis / Exocytosis |
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Henderson-Hasselbach Equation
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pH = pKa + log [B] / [A]
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