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14 Cards in this Set
- Front
- Back
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where would one see the perhydrocyclophentanophenanthrene ring?
p112 |
corticosterioids
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t/f all corticosterioids are created equal. t/f there aren't big differences in their anti-inflammatory actions t/f there are significant differences in their ability to modify electrolyte lalance and blood volume (mineralocorticoid activity)
p 112 |
all corticosterioids are NOT created equal
there ARE significant differences in anti-inflammatory actions and ability to modify their electrolyte balanc and blood volume |
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the standard generic/trade name of cotrticosterioids is what?
#'s: 25 mg, 1 anti inflamm action, 1 relative Na-retain activity p112 |
cortisol (generic) CORTEF (trade) is the standard. other generic names: perdnisolone, triamcinolone and dexamethasone
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what are the 4 steps of corticosterioid action?
p112 |
sterioids in and interact w/ sterioid R in cytoplasm. 2. interaction alters the conformation of sterioid R & facilitates translocation of complex into nucleus 3. binds DNA = inhibition or induction of transcription 4. new mRNA to proteins = physiological changes
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many actions of sterioids involve _____ actions with other hormones ie. _______ actions
p113 |
many roids involve concerted actions w/ othe hormones
ie permissive actions |
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more metabolic actions b/c more enzyme production b/c sterioids, also anti-inflammatory and immunosupressive activities of roids w/ endothelial, leukocytes, lymphocytes and fibroblasts include what?
p113-114 |
inhibition of COX 1/2 (decreasing pg's and thromboxanes), more lipocortin 1 (mediator) --> inhibiting phospholipase A2, blocking eicosanoids.
inhibit upregulation of adhesion molecules in endothelial cells, less emigration of leukocytes inhibit cytokine production and histamine release |
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what are: prednisolone, hydrocortisone, dexamethasone and triamicinolone? when ar they used in dentistry?
p114 |
1. tmj arthritis.
2. emergency (for shock, if adrenally insufficient) 3. oral inflamm. 4. prophylaxis in adrennally insufficient 5. prophylaxis w/ antibiotics |
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indications for dental streroids?
p114 |
recurrent aphthous stomatitis
denture stomatitis oral lichen planus chronic ncecrotizing ulcerative gingivitis pemphigus |
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what is the major dental indication for sterioids?
p114 |
oral inflammation.
it's exteremely inportant that a good differential diagnosis rules out viral or bacterial origins of the inflammation |
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prophylaxis with antibiotics: take corticosterioids chronically and you can become what?
p115 |
take corticosterioids chronicall you can become immunocompromised. lowers host defence mechanisms.
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contraindications are usually for systemic glucocorticoids, but less mild when topically administered. what are contraindications of corticosterioids?
p115 |
viral/fungal infections
TB Diabedes mellitius (sterioids increase insulin demand by increasing blood glc) pregnancy (1st tm = cleft lip) myasthenia gravis |
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why is myasthenia gravis a contraindication for corticosterioids?
p115 |
roids associated with severe deterioration of muscle strength that is refractory to AChEIs, ... mechanical ventillation required
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Caution should be used for corticosterioids for what 4 things?
p115-116 |
peptic ulcer
psychoses eye problems hypokalemia |
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Long term sterioids, side effects 2?
p116 |
cushing's syndrome - irregular deposition of fat, "moon face" and edema
osteoporosis - see bone loss, and increased fracture risk |
