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23 Cards in this Set
- Front
- Back
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What bugs does Vancomycin affect?
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G+ ONLY
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Does vancomycin have good oral absorption?
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no it doesnt, but this can be used to treat C diff
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How does vancomycin work?
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this is a bacteriacidal, and interrupts the D-ala-D-ala transpeptidation of bacterial wall side chains
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Does vancomycin affect G-?
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no it does not
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What is vancomycin typically used to treat?
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penicillin and methicillin resistant G+ organisms
Or penicillin allergic pts |
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What can vancomycin be combined with to treat methicillin resistant organism?
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aminoglycosides
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Does Vancomycin penetrate the CSF?
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no it does not
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How is Vancomycin typically administered?
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IV
it is painful IM, and not orally absorbed |
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What are the two major adverse reactions of Vancomycin ?
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Ototoxic/nephrotoxic
Red Man syndrome- flushing from histamine release |
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What is fosfomycin?
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this is a cell wall inhibitor
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What bugs does fosfomycin affect?
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G+ and G-
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What types of infections is fosfomycin typically given for?
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uncomplicated UTIs
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What is Bacitracins method of action
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this interferes with the final dephosphorylation step in the phospholipid carrier cycle
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What is Bacitracins spectrum?
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G+ mostly
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What are the major side effects of Bacitracins?
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serious nephortoxicity
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What is Bacitracin usually given for?
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topically with polymyxins to treat ocular/skin infections
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What is cycloserine?
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this is a cell wall inhibitor
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How does cycloserine work?
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this competes with d-ala for enzymes which are used in incorportating D-ala into the wall
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What is cycloserine typically used against?
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2nd line broad spectrum that treats TB and UTI's
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How does cycloserine work?
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inhibits L ala racemase and D ala synthestase
by competing with D ala |
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What are the side effects of cycloserine
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severe CNS effects of many different types
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What does bacitrain effect?
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G+ mostly
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What actually causes red man syndrome with vancomycin?
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histamine release
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