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69 Cards in this Set
- Front
- Back
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What types of immune responses are more easily suppressed?
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primary
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When do you give the most immune suppression for organ transplants?
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right after transplant
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How long does it take the immunosuppressive effect for corticosteroids to develop?
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slowly
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What is the immunosuppressive effect of corticosterooids?
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depresses macrophages, lympholytic*
decreased cytokines |
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What are the long term immunosuppressive effects of corticosteroids?
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decreased allergic and autoimmune responses
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What are the major side effects of immunosuppressive?
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cushings
osteoprosis peptic ulcers menstrual/reproductive effects |
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What do T cell suppressants do?
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prevent rejection of transplants
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What does cyclosporine do?
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selectively inhibits T cells
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How does cyclosporine work?
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inhibits calcineurin/ T cell activation
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What cytokines does cyclosporine affect?
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decreased IL-1, IL-2
increased TGF-B |
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Does cyclosporine affect bone marrow?
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no it does not
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Can you switch generics with cyclosporine?
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NOpe
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What metabolizes cyclosporine?
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CYP3A4
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What cant you drink with cyclosporine?
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grapefruit juice
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What is cyclosporine used for?
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prevent rejection
maintenance following organ transplant autoimmune disease |
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What are the main toxic effects of cyclosporine?
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Renal tox*
hypertension gingival hyperplasia |
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How does Tacrolimus/FK506 work?
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inhibits calcineurine
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what does Tacrolimus/FK506 do to T cells?
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inhibits T cell activation
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How does Tacrolimus/FK506 affect cytokines?
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decreased IL2/4
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What is Tacrolimus/FK506 used for?
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prevent rejection in transplants, mostly Liver
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What are the main toxic problems with Tacrolimus/FK506 ?
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nephrotoxic
hypertension hyperglycemia neurotoxic |
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How is Tacrolimus/FK506 given?
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orally
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What metabolizes Tacrolimus/FK506 ?
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CYP3A4
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What cant you drink with Tacrolimus/FK506 ?
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grapfruit
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What does Pimecrolimus do?
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treats atopic dermatitis without damaging skin
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What does Sirolimus do?
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inhibits T cell proiferation in response to IL-2
inhibits B cell proliferation |
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What is the toxic effect of Sirolimus?
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bone marrow suppression
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How does Mycophenolate work?
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inhibits monophosphate dehydrogenase
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What cells does Mycophenolate affect?
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ONLY T and B cells
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What is Mycophenolate used for?
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prevent rejection after transplants
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What are the side effects of Mycophenolate?
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rash
N/V leukopenia |
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Who should not get Mycophenolate?
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pregnant women
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How does Azathioprine work?
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inhibits De novo purine synthesis
as it is converted into 6-mercaptopurine |
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What does Azathioprine do?
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inhibits cell proliferation
prevents rejection |
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What does Azathrioprine treat?
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glomerulonephritis and severe RA
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What are the major side effects of Azathioprine?
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bone marrow suppression
teratgoenic |
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What metabolizes Azathioprine
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xanthine oxidase
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how does Leflunomide work?
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inhibits de novo pyrimidine synthesis
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what does Leflunomide do?
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inhibits proliferation of T cells, and B cells
decreased TNF alpha |
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How does cyclophosphamide stand out?
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can inhibit an established immune response!
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What is the major side effect of cyclophosphamide?
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hemorrhagic cysitis
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What cytokines does thalidomide affect?
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TNFalpha, IL-6 decreases both
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What is muromonab?
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this is an antibody against CD3
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What is muromonab used for?
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steroid resistant rejection, kidney rejection
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How does muromonab affect cels?
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depletes T cells !
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What are the toxic effects of muromonab?
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cytokine release syndrome
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What does Daclizuman/Basilixumab do?
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binds IL-2 on activated T cells
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When is Daclizuman/Basilixumab used?
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used right at transplant for induction of immunosuppresion
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What cytokines does thalidomide affect?
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TNFalpha, IL-6 decreases both
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What is muromonab?
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this is an antibody against CD3
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What is muromonab used for?
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steroid resistant rejection, kidney rejection
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How does muromonab affect cels?
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depletes T cells !
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What are the toxic effects of muromonab?
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cytokine release syndrome
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What does Daclizuman/Basilixumab do?
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binds IL-2 on activated T cells
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When is Daclizuman/Basilixumab used?
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used right at transplant for induction of immunosuppresion
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What does Efalizumab bind?
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CD-11a
prevents ICAM binding |
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What conditions does Efalizumab treat?
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psoriasis
prevents T cell activation |
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What does Alefacept bind?
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CD-2
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what does Alefacept treat?
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psoriasis
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What does Omalizumab bind?
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Anti IgE
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What does Rituximab treat?
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B cells in non-hodgkin lymphoma
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What does Infiliximab treat?
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neutralizes TNF alpha, used for RA
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What does Operlvekin do?
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this prevent chemotherapy induced thrombocytopenia
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How does Operlvekin work?
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this is recombinant IL-11
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What does G-CSF treat?
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severe neutropenia
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What interferone alfa-n-3 treat?
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condylomata accuminata
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What does interferon beta-1b treat?
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multiple sclerosis
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What does Glatiramer treat?
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multiple sclerosis, this is a decoy for myelin basic protein
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What does interferon gamma-1b do?
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activates pathgocytes and macrophages
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