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15 Cards in this Set
- Front
- Back
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What kind of drug is Daptomycin?
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this is a lipopeptide antibiotic
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How does Daptomycin work?
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this binds to bacterial membranes and causes a rapid depolarization
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How do Daptomycin affect G+?
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these are bactericial against G+
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How is Daptomycin given?
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IV administration
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How is Daptomycin excreted?
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by the kidneys, unchanged
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What is Mupirocin?
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this is bactroban, and antibiotic that is unrelated to all other antibiotics structurally
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How does mupirocins activity change with dose?
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low dose- bacteriostatic
high dose- bacteriocial |
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How does mupirocin work?
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this reversible binds bacterial isoleucyl-tRNA synthetase
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How is mupirocin given?
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topically
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What does mupirocin treat?
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impetigo caused by staph A
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How does polymyxin B work?
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binds to G- bacterial cell wall phospholipids
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How is polymyxin B excreted?
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slowly, through the kidney
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When is polymyxin B used?
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when other antibiotics down work
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What is the toxicity of polymyxin B?
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nephrotoxicity
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What is polymyxin E used for?
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this works against G-, but safer and more effective agents work
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