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20 Cards in this Set
- Front
- Back
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What are the 4 main unique points of chemotherapy specificity?
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more toxic to parasite than host
selects for resistant strains hypersensitivity can be a problem used to lower microorganism load, so the body can work |
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What type of drug is maintenance of constant blood levels most importnat for?
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bacteriostatic drugs
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How does chemotherapy affect drug resistant strains?
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this SELECTS for them to live, which is BAD
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What are the 6 mechanisms that chemotherapy selects for drug resistant strains
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bug does absorb drug
bug inactives drug bug pumps drug out drug cant bind modified target too many target molecules altered metabolic pathway dodges target |
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What is the most common way drug resistance is passed along?
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horizontal transfer- from another species that is resistant
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What are the three methods of horizontal transmission?
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transformation, transduction, conjugation
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Are drug resistance mutations a result of exposure to the drug itself?
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No they are not
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How does transduction occur?
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a bacteriophage is used to give a new bacteria a resistance plasmid
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How do bugs get resistance from conjugation? what type of resistance?
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these can transfer multiple drug resistance during conjugation with a sex pilus
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What type of bugs typically use conjugation?
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G- bacilli
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What three types of bugs now have strains resistant to ALL known drugs?
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Enterococci
pseduomonas enterobacter |
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How do marcolides work?
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50S, inhibit translocation
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How does Chloramphenicol work?
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50S, inhibits transpeptidation
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How do aminglycosides work?
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30S, block initation compelx
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How do tetracyclines work?
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30S, prevent binding incoming charged tRNA
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How do fluroquinolones work?
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inhibiting toposiomerase
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How does Rifampin work?
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inhibits DNA dependent RNA polymerase
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How do sulfonamides work?
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inhibit folic acid synthesis
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How do beta lactams work?
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inhibit bacterial cell wall synthesis
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How does vancomycin work?
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inhibits peptidoglycan chain elongation?
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