Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
What does Km relate to?
|
1/2 V max
|
|
|
What does Km reflect?
|
the affinity of the enzyme for its substrate
|
|
|
When looking at charts of 1/v and 1/[s] - how do competitive inhibitors lines relate to each other?
|
these cross competitively, while non competitive inhibitors do not cross
|
|
|
how do noncompetitive inhibitors effect Vmax?
|
these decrease Vmax
|
|
|
pH-pKa=log (A-)/(HA) for acids
|
pH-pKa= log (B)/(BH+) for bases
|
|
|
What is the equation for Vd, volume of distribution?
|
amount of drug given in body/ plasma drug concentration
|
|
|
what is the equation for clearance?
|
Vd X Ke (elimination constant)
|
|
|
What is the equation for half life?
|
(.7 x Vd)/ CL
|
|
|
What is the loading dose calculation?
|
target concentration X Vd/fraction available
|
|
|
What is the equation for concentration at steady state?
|
Css= (F* (D/t))/CL
f= fraction available D= dose t= dosing interval |
|
|
What drugs are eliminated with 0 order kinetics ?
|
phenytoin, ethanol, aspirin
|
|
|
What are the phase 1 metabolism reactions?
|
reduction, oxidation, hydrolysis- makes water soluble metabolites
|
|
|
what are the phase 2 metabolism reactions?
|
acetylation, glucuronidation, sulfation- creates polar inactive, renal excretion
|
|
|
How do you measure the therapeutic index?
|
LD50/ED50
|
