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20 Cards in this Set
- Front
- Back
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inducers of CYP450
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Rifampin, smoking, phenytoin
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inhibitors of CYP450
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Ketoconazole, grape fruit juice, clarithromycin
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phase I
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introduces or exposes a functional group on the parent compound yielding a water souble compound
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phase II
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enzymes catalzye the conjugation of the drug with another molecule to produce a metabolite with improved water solubility and elimination of the drug from the tissue
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regulatory proteins
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mediate the actions of endogenous chemical signals such as neurotransmitters and hormones
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enzymes
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ex: dilhydrofolate reducatse, the receptor of methotrexate
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transport proteins
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Na, K, ATPase - the receptor digoxon
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structural proteins
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tubulin- the receptor of colchicine
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competitive antagonist
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drug competes with an agonist for the receptor building site
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reversible antagonist
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drug is not tightly bound to the receptor which can allow for binding of an agonist
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where does the pro-drug go to be activated
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liver
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what factors affect absorption
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dose, formulation, bioavaliablity
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class A drugs in pregnancy
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really safe
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class B drugs in pregnancy
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lil to no effect
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Class C drugs in pregnancy
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not controlled studies, possible side effects
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Class D drugs in pregnancy
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side effects but if risks weigh out for the mother than should be taken
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Class x drugs in pregnancy
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don't use - high risk
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why should you not use intramuscular drugs
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can go straight into the baby, thin lining
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does a fetus or adult have more water
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fetus
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what is so important to remember about neonates blood brain barrier
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they don't have one
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