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3 Cards in this Set
- Front
- Back
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Atorvastatin (Lipitor)
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-in combo with diet modification and exercise, to lower LDL cholesterol
-baseline lipid profile, which has total cholesterol, LDL and HDL cholesterol levels, and TGs (VLDLs); also LFTs and a CK level -not with viral or alcoholic hepatitis and preggos -caution-nonalcoholic fatty liver disease, those consume alcohol to excess, those taking fibrates or ezetimibe or agents that inhibit CYP34A (cyclosporine, erythromycin, ketoconazole, ritinavir) -oral; evening prefered -cholesterol levels monitored monthly early in treatment and at longer intervals thereafter -hepatotoxicty; liver function before therapy and every 6-12 months following; serum transaminase more than 3x ULN, stop -myopathy-notify prescriber if unexplained muscle pain or tenderness develops-if it does, CK level not more than 10 x UNL or withdraw -id CHD risk factors-smoking, obesity, men over 45, women over 55, family hx of premature CHD, a personal hx of cerebrovascular or peripheral vascular disease, reduced levels of HDL (below 40 mg/dL), HTN, diabetes is risk equivalent -diet modification precede and accompany drug therapy; arrange for dietary counseling; less than 200 mg cholesterol per day and saturated fat less than 7% of caloric intake-if not work, add soluble fiber and plan stanols or sterols to regimen -help pt establish appropriate exercise regimen -cigarette quit, obese lose weight; treat DM and HTN -continuous therapy and adhere to the regimen, continue lifelong |
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gemfibrozil (lopid)
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decreases triglyceride levels and raises HDL levels and not reduce LDL cholesterol to a significant degree
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simvastatin (zocor)
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-in combo with diet modification and exercise, to lower LDL cholesterol
-baseline lipid profile, which has total cholesterol, LDL and HDL cholesterol levels, and TGs (VLDLs); also LFTs and a CK level -not with viral or alcoholic hepatitis and preggos -caution-nonalcoholic fatty liver disease, those consume alcohol to excess, those taking fibrates or ezetimibe or agents that inhibit CYP34A (cyclosporine, erythromycin, ketoconazole, ritinavir) -oral; evening prefered -cholesterol levels monitored monthly early in treatment and at longer intervals thereafter -hepatotoxicty; liver function before therapy and every 6-12 months following; serum transaminase more than 3x ULN, stop -myopathy-notify prescriber if unexplained muscle pain or tenderness develops-if it does, CK level not more than 10 x UNL or withdraw -id CHD risk factors-smoking, obesity, men over 45, women over 55, family hx of premature CHD, a personal hx of cerebrovascular or peripheral vascular disease, reduced levels of HDL (below 40 mg/dL), HTN, diabetes is risk equivalent -diet modification precede and accompany drug therapy; arrange for dietary counseling; less than 200 mg cholesterol per day and saturated fat less than 7% of caloric intake-if not work, add soluble fiber and plan stanols or sterols to regimen -help pt establish appropriate exercise regimen -cigarette quit, obese lose weight; treat DM and HTN -continuous therapy and adhere to the regimen, continue lifelong |
