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15 Cards in this Set
- Front
- Back
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What pathway is responsible for the parkinsonian symptoms?
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Nigrostriatal pathway
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What pathway is responsible for increased prolactin secretion?
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The tuberoinfundibular system pathway
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What pathways are responsible for the psychosis symptoms?
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The mesolimbic-mesocortical pathway
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Which receptors have a low affinity for most antipsychotic drugs?
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D1 and D5
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Which receptors are both on the pre and post synaptic terminals?
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D2 and D4
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Which receptor is located in all the important dopaminergic pathways?
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D2
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Which receptors do FGA's block?
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D2. Their binding affinity to these receptors is strongly correlated with clinical antipsychotic and extrapyramidal (Parkinson-like symptoms)
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Where are D4 receptors found at the highest evels?
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Mesolimbic and mesocortical arms of the dopaminergic system
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What are the major classes of FGAs?
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Phenothiazines
Butyrophenomes |
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How do FGAs act?
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They decrease dopamine activity in the mesolimbic system by blocking D2 receptors. Their actions are mainly on the positve symptoms of schizophrenia. They do not work well for the negative symptoms and may even increase them.
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Describe the non-psychosis applications of phenothiazines, particularly chlorpromazine.
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THey are useful in abolishing or dominishing the intensity or incidence of emesis, controllin intractable hiccoughts, or managing the abnormal motor movements in Huntington's chorea.
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What are the side effects of high potency FGAs?
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-Extrapyramidal side effects (EPS) (dystonias; Parkinsonian symptoms; akathisia).
-EPS may lead to tardive dyskinesia (TD), which are presistent, involuntary and abnormal mlovement refractory to treatment (grimacing, tongue prorusion, lip smacking, puckering, rapid eye blincking or movements of the fingers, arms, legs and trunchs |
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What are the side effects of low potency FGAs?
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Sedation
Alpha1 receptor blocade -Hypotension Anticholinergic effects -Dry mouth -Constipation |
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What are the low potency FGAs?
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Chlorpromazine
Thioridazine |
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What are the high potency FGAs?
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Trifluoperzine
Haloperidol |
