Pharmacology- Psychiatry Antidepressant

Front 1

Tricyclic Antidepressants
-Mechanism

Back 1

Block reuptake of Norepinephrine and Serotonin

Front 2

Imipramine
-Clinical use

Back 2

Bedwetting (TCA)

Front 3

Clomipramine
-Clinical use

Back 3

OCD (TCA)

Front 4

Tricyclic antidepressants
-Toxicity
-What can you use for one of the toxicities?

Back 4

3 C's- Convulsion, Coma, Cardiotoxicity (arrthymias) NaHCO3 for CV toxicity
Also respiratory depression, hyperpyrrexia. Confusion and hallucination due to anticholinergic side effects in elderly so use nortriptyline

Front 5

Tricyclic antidepressants
-Side Effects

Back 5

Sedation, alpha-blocking effects, atropine-like (anticholinergic effects (Tachycardia and Urinary retention))
third degree TCA (amitryptiline more anticholinergic than 2nd degree.

Front 6

Which TCA is least sedating?

Back 6

Desiprmaine

Front 7

What type of drug is it?
-Imipramine

Back 7

TCA

Front 8

What type of drug is it?
-Amitriyptiline

Back 8

TCA

Front 9

SSRI's
-Mechanism

Back 9

Serotonin-specific reuptake inhibitor

Front 10

SSRI's
-Clinical use

Back 10

Depression, OCD

Front 11

SSRI's
-Toxicity

Back 11

First off it takes 2-3 weeks for its effect
A) GI distress
B) Sexual Dysfunction (Anorgasmia)
C)"Serotonin syndrome" with any drug that increases serotonin (Eg. MAO inhibitors) --> Hyperthermia, muscle rigidity, CV Collapse, flushing, diarrhea

Front 12

What type of drug is it?
-Fluoxetine

Back 12

SSRI's

Front 13

What type of drug is it?
-Sertraline

Back 13

SSRI's

Front 14

What type of drug is it?
-Citalopram

Back 14

SSRI's

Front 15

Bupropion
-Mechanism

Back 15

Increases Norepinephrine and Dopamine (unknown medchanism)

Front 16

Bupropion
-Toxicity

Back 16

Stimulant effect (Tachycardia, insomnia), Headache, seizure in bulimic patients. No sexual side effects

Front 17

Bupropion
-Used for

Back 17

Smoking cessation

Front 18

Venlafaxine
-Mechanism

Back 18

Inhibits Serotonin and Norepinephrine reuptake

Front 19

Venlafaxine
-Toxicity

Back 19

Increase BP and stimulant effects, sedation and nausea

Front 20

Venlafaxine
-Clinical use

Back 20

General Anxiety disorder

Front 21

Duloxetine
-Mechanism

Back 21

Inhibits Serotonin and Norepi reuptake (similar to venlafaxine but more effect on NE)

Front 22

Duloxetine
-Toxicity

Back 22

Same as Venlafaxine
Increase BP and stimulant effects, sedation and nausea

Front 23

Duloxetine
-Clinical use

Back 23

Diabetic peripheral neuropathy

Front 24

Mirtazapine
-Mechanism

Back 24

Alpha-2 Antagonist (increase release of NE and serotonin) and potent 5-HT2 and 5-HT3 receptor anatgonist

Front 25

Mirtazapine
-Toxicity

Back 25

sedation, increase appetitie, weight gain, dry mouth

Front 26

Maprotiline
-Mechanism

Back 26

Blocks NE reuptake

Front 27

Maprotiline
-Toxicity

Back 27

Sedation, orthostatic Hypotension

Front 28

Trazodone
-Mechanism

Back 28

primarily inhibits serotonin reuptake

Front 29

Trazodone
-Clinical use

Back 29

Insomnia, high doses for antidepressant effect

Front 30

Trazodone
-Toxicity

Back 30

Sedation, nausea, priapism, postural hypotension

Front 31

MAO inhibitors
-Mechanism

Back 31

Nonselective MAO inhibition --> Increase level of amine neurotransmitter

Front 32

MAO inhibitor
-Clinical use

Back 32

Atypical depression, anxiety, hypochondriasis

Front 33

MAO inhibitor
-Toxicity

Back 33

Hypertensive crisis with tyramine ingestion (in many foods) and beta-agonists CNS stimulation
Contraindicated with SSRI or meperidine (To prevent serotonin syndrome)

Front 34

What type of drug is phenelzine?

Back 34

MAO inhibitor

Front 35

What type of drug is Tranylcypromine?

Back 35

MAO inhibitor