Pharmacology: Parasympathetic

Front 1

rate limiting step of cholinergic neurotransmission is ___

Back 1

Ch uptake

Front 2

ACh is synthesized by ___ from ___ and ___

Back 2

choline acetyltransferase (ChAT)
choline
Ac CoA

Front 3

hemicholinium inhibits ___

Back 3

Ch uptake

Front 4

botulinum Tx inhibits ___

Back 4

ACh exocytosis

Front 5

muscarinic receptor structure

Back 5

7TM GPLR

Front 6

nicotinic receptor structure

Back 6

5 subunit pentamer

Front 7

M1, M3 and M5 signal via ___. M2 and M4 signal via ___

Back 7

Gq
Gi

Front 8

M1 is present in ___ (2).

Back 8

nerves
brain

Front 9

M2 is present in ___ (3)

Back 9

cardiac muscle
nerves
GIT smooth muscle

Front 10

M3 is present in ___ (3)

Back 10

glands
smooth muscle
endothelium

Front 11

N1 is also called ___ and is present in ___

Back 11

NN
dendrites & somata of post-ganglionic cells

Front 12

effects of cholinergic agonists on eye (2)

Back 12

contraction of iris sphincter -> miosis
contraction of ciliary muscle -> accomodation

Front 13

effects of cholinergic agonists on SA node

Back 13

negative chronotropy

Front 14

effects of cholinergic agonists on atria

Back 14

decreased contractility

Front 15

effects of cholinergic agonists on AV node (2)

Back 15

decreased refractory period
decreased conduction velocity

Front 16

effects of cholinergic agonists on ventricles (2)

Back 16

increased refractory period
small decrease in contractility

Front 17

effects of cholinergic agonists on blood vessels at low & high dose

Back 17

low dose: vasodilation via endothelial M3 mediated NO release
high dose: vasoconstriction via direct action on smooth muscle M3

Front 18

methacholine acts most strongly on ___. Is it susceptible to ChE? Does it have nicotinic action?

Back 18

heart
yes
yes, weak

Front 19

carbachol acts most strongly on ___ (2). Is it susceptible to ChE? Does it have nicotinic action?

Back 19

GIs smooth muscle
bladder
no
yes, strong

Front 20

bethanechol acts most strongly on ___ (2). Is it susceptible to ChE? Does it have nicotinic action?

Back 20

GIs smooth muscle
bladder
no
no

Front 21

___ can cause excitation block, leading to ___

Back 21

carbachol
flaccid paralysis

Front 22

cisapride action (2 steps)

Back 22

agonizes 5-HT4R in myenteric plexus
postganglionic cell releases ACh

Front 23

metoclopramide action (3 steps)

Back 23

agonizes 5-HT4R and antagonizes DA
reduces GI inhibition from DA
causes ACh release

Front 24

AChE anionic site function (2)

Back 24

binds quaternary amine
positions ACh

Front 25

AChE esteratic site function

Back 25

attacks the acyl carbon

Front 26

because of ___, pyridostigmine and neostigmine are used to treat MG

Back 26

no CNS action

Front 27

edrophonium is a short acting AChE inhibitor because ___. it is used for ___ (2).

Back 27

it doesn't bind covalently to the esteratic site
diagnosing MG
managing MG drug doses

Front 28

criteria for MG diagnosis (2)

Back 28

alleviation of symptoms with edrophonium
no tongue fasciculation

Front 29

___ can undo phosphorylation of AChE, but not after ___.

Back 29

oxime aka PAM
aging

Front 30

of the 4 short/medium duration AChE inhibitors, only ___ affects CNS, because ___

Back 30

physostigmine
it's a tertiary amine so it can cross BBB

Front 31

3 long duration AChE inhibitors are ___. they are used for ___.

Back 31

tacrine
donepezil
rivastigmine
Alzheimer's

Front 32

treatment for glaucoma is either ___ or ___

Back 32

muscarinic agonist
AChE inhibitor

Front 33

rocuronium is metabolized by

Back 33

liver

Front 34

2 short-acting non-depolarizing ACh blockers

Back 34

rocuronium
mivacurium

Front 35

mivacurium is metabolized by

Back 35

plasma ChE