Pharmacology -Osteoporosis Drugs

Front 1

Calcitonin (Cibacalcin, Calcimar, Miacalcin)

Class?
MOA?
SEs?
Uses?
Route?

Back 1

Calcitonin (Cibacalcin, Calcimar, Miacalcin)

Class -Biphospahtes

MOA -1)Works with PTH to regulate calcium homeostasis. 2) Reduces PTH concentrations 3) Inhibits osteoclasts. 4) Inhibits tubular reabsorption of Ca++

Uses -Tx osteoporosis, Paget's disease, Hypercalcemia

SEs -Nasal irritation, dryness, inflammation at the site of injection

Route -Intranasal, IM, SubQ

Front 2

Alendronate (Fosamax)
Ibandronate (Boniva)

Tell me all about them!
What's special about how you give them?

Back 2

Alendronate (Fosamax)
Ibandronate (Boniva)

Class -Biphospahtes

MOA -Inhibits reabsorption of bond by osteoclasts

Uses -Prevent osteoporosis, established osteoporosis, and paget’s disease, tx cancer pain

SEs -Ulceration, esophagitis, musculoskeletal pain, ocular problem, GI irritation (remain upright for minimum 30 min.)

Route -Oral, low bioavailability so take with full glass of water (no food)

Front 3

Raloxifene (Evista)

Class? MOA? Uses? SEs?

Back 3

Raloxifene (Evista):

Class -Selective Estrogen Receptor Modulators (SERMs)

MOA -1) Selective action to inhibit osteoclasts activity by interaction with estrogen receptors in bone 2) increase calcium absorption 3) promote synthesis of Calcitonin 4) antagonize receptors in the endometrium and breasts and the action of PTH through another mechanism

Uses -Prevent osteoporosis in postmenopausal women

SEs -Pregnancy category X, stroke, DVT, PE, leg cramps, hot flashes

Front 4

Teriparatide (Forteo)

Class, MOA, uses, SEs, Route?

Back 4

Teriparatide (Forteo):

Class - Parathyroid hormone

MOA - Modulates metabolism of Ca++ and PO4 like natural PTH, activates bone remodeling unit, increases bone formation

Use - Increases bone density and strength; used for patient at risk for fracture from osteoporosis or from corticosteroid use

SEs- Rare bone cancer, N/D, mild headache, back pain

Route - SubQ