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21 Cards in this Set

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inhibitor of serotonin storage used for atypical depression, narcolepsy, adn obstructive sleep apnea

side effects: cardiac, hypertension, dizziness, insomina, agitation, rhinitis
Modafinil
inhibitors of serotonin degradation used for depression

side effects: systemic tyramine toxicity from consumption of foods that contain tyramine (hypertensive crisis), fever due to increased muscle tone, leukopenia, hepatic failure, drug induced lupus, worsening of depression, dizziness, somnolence, orthostatic hypotension, weight gain, increased liver aminotransferase level, orgasm disorder

contraindications: concomitant use of sympathomimetics, bupropion, buspirone, guanethidine, MAOI's, methyldopa, L dopa, L tryptophan, L tyrosine, phenylalanine, CNS depressants, narcotics, dextromethorphan, excessive coffee/chocolate intake, foods with high tyramine, liver disease, pheochromocytoma, HF, general anesthesia/anesthesia with vasoconstrictors
iproniazid, phenelzine, isocarboxazid
inhibitor of serotonin storage used for depression

side effects: systemic tyramine toxicity from consumption of foods that contain tyramine (hypertensive crisis), fever due to increased muscle tone, leukopenia, hepatic failure, drug induced lupus, worsening of depression, dizziness, somnolence, orthostatic hypotension, weight gain, increased liver aminotransferase level, orgasm disorder
***** LESS TYRAMINE TOXICITY*****

contraindications: concomitant use of sympathomimetics, bupropion, buspirone, guanethidine, MAOI's, methyldopa, L dopa, L tryptophan, L tyrosine, phenylalanine, CNS depressants, narcotics, dextromethorphan, excessive coffee/chocolate intake, foods with high tyramine, liver disease, pheochromocytoma, HF, general anesthesia/anesthesia with vasoconstrictors
moclobemide, befloxatone, brofaromine
inhibitor of serotonin degradation used for depression

side effects: systemic tyramine toxicity from consumption of foods that contain tyramine (hypertensive crisis), fever due to increased muscle tone, leukopenia, hepatic failure, drug induced lupus, worsening of depression, dizziness, somnolence, orthostatic hypotension, weight gain, increased liver aminotransferase level, orgasm disorder
***** LESS TYRAMINE TOXICITY*****

side effects: systemic tyramine toxicity from consumption of foods that contain tyramine (hypertensive crisis), fever due to increased muscle tone, leukopenia, hepatic failure, drug induced lupus, worsening of depression, dizziness, somnolence, orthostatic hypotension, weight gain, increased liver aminotransferase level, orgasm disorder
***** LESS TYRAMINE TOXICITY*****

contraindications: concomitant use of sympathomimetics, bupropion, buspirone, guanethidine, MAOI's, methyldopa, L dopa, L tryptophan, L tyrosine, phenylalanine, CNS depressants, narcotics, dextromethorphan, excessive coffee/chocolate intake, foods with high tyramine, liver disease, pheochromocytoma, HF, general anesthesia/anesthesia with vasoconstrictors
*****GREATER FREEDOM WITH DIET*****
Selegiline
drugs used for depression, pain syndromes, nocturnal enuresis (I), and OCD (c)

side effects: heart block, cardiac arrhythmias, orthostati c hypotension, MI, agranulocytosis, jaundice, seizure, worsening of depression with suicidal thoughts, bloating, constipatino, xerostomia, dizziness, somnolence, blurred vision, urinary retention

contraindications: concomitant use of MAOI, cardiac conduction defects, use in patients after an acute MI
tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepine, imipramine, nortriptyline, trimipramine
drugs used for depression, anxiety, OCD, post traumatic stress disorder, pain syndrome

side effects: serotonin syndrome, may precipitate mania in BPAD, sexual dysfunction, GI distress, vasospasm, sweating, somnolence, anxiety

contraindications: concomitant use of MAOI, pimozide, or thioridazine
SSRI's: citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
drugs used for depression, anxiety, panic disorder, pain syndromes (D)

side effects: neuroleptic malignant syndrome, hepatitis, may exacerbate mania/depression in susceptible patients, hypertension, sweating, weight loss, GI distress, blurred vision, nervousness, sexual dysfunction

contraindications: concomitant use of MAOI
venlafaxine and duloxetine
drug used for depression and smoking cessation

side effects: tachyarrhythmia, hypertension (esp if combined with nicotine patch), may exacerbate mania in susceptible patietns, pruritus, sweating, rash, dyspepsia, constipation, dizziness, tremor, blurred vision, agitation

contraindications: seizure, bulimia/anorexia, concomitant MAOI, abrupt discontinuation of alcohol or sedatives
bupropion
drug used for depression

side effects: agranulocytosis, seizure, may exacerbate mania/depression in susceptible patients, somnolence, increased appetite, hyperlipidemia, constipation, dizziness

contraindication: concomitant use MAOI
mirtazapine
drugs used for depression and insomnia (t)

side effects: priapism, orthostatic hypotension, liver failure, seizure, may worsen mania/depression, sweating, weight change, dyspepsia, dizziness, somnolence, blurred vision

contraindications: coadministration of MAOI, pimozide, trizolam, carbamazepin
nefazodone, trazodone
serotonin receptor agonist used for anxiety

side effects: ischemia/MI, cerebrovascular accitdent, dizziness, confusion, headache, excitement, blurred vision, hostile feeling/behavior, nervousness
buspirone
serotonin receptor agonist used for migraine headaches

side effects: coronary artery spasm, hypertensive crisis, ischemia/MI, cerebrovascular accident, seizure, chest pain, flushing, nausea, dizziness

contraindications: ergot agent, concomitant MAOI, ichemic cardiac/cerebrovascular/peripheral vascular syndromes, uncontrolled hypertensino
sumatriptan, rizatriptan, almotriptan, frovatriptan, eletriptan, zomitriptan
serotonin receptor antagonist used for glaucoma and hypertension

side effects: orthostatic hypotension, Vtach, flushing, rash, fluid retention, dyspepsia, dizziness, sedation
ketanserin
serotonin receptor antagonist used for nausea

side effects: cardia arrhythmia, bronchospasm, increased liver enzymes, constipation, diarrhea, fatigue, headache
ondansetron
serotonin receptor antagonist used for IBS with constipation predominance

side effects: hyptension syncope, diarrhea, dizziness, headache

contraindications: history of bowel obstruction, abdominal adhesions/symptomatic gallbladder disease, moderate to severe hepatic impairment, severe renal impairment, suspected sphincter of Oddi dysfunction
Tegaserod and Prucalopride
serotonin receptor antagonist used for IBS with diarrhea predominance

side effects: severe constipation, acute ischemic colitis, abdominal pain, nausea, headache

contraindications: pre existing constipation, concurrent use of fluvoxamine, crohn's disese, UC, diverticulitis, severe hepatic impairment, history of hypercoaguable state, history of impaired intestinal circulation, instestinal stricture, ischemic colitis, toxic megacolon
alosetron
drug used for bipolar affective disorder

side effects: acute drug intoxication, severe bradyarrhythmia, hypotension, sinus node dysfunction, hyperkalemia, pseudotumor cerebri, increased intracranial pressure and papilledema, seizure, polyuria, nephrogenic DI, hypothyroidism, goiter, ECG and EEG abnormalities, diarrhea, nausea, muscle weakenss, transient visual field scotoma, renal impairment, acne

contraindications: severe debilitation, dehydration, sodium depletion, significant cardiovascular disease, significant renal impairment, lactation
lithium
drug used for partial and toic clonic seizures, BPAD, and trigeminal neuralgia

side effects: aplstic anemia, agranulocytosis, thrombocytopenia, leukopenia, AV blck, arrhythmias, Steven Johnson syndrome, toxic epidermal necrolysis, hyponatremia, hypocalcemia, SIADH, porphyria, hepatitis, nephrotoxicity, blood pressure lability, rash, confusion, nystagmus, blurred vision

contraindications: comcomitant use MAOI, history bone marrow depression
Carbamazepine
drug used for partial adn tonic clonic seizures, atypical absence siezures, and BPAD

side effects: Steven Johnson syndrome, toxic epidermal necrolysis, bone marrow suppression, hepatic necrosis, amnesia, angioedema, rash, ataxia, somnolence, burred vision
lamotrigine
drug used for tonic clonic seizures, absence siezures, atypical absence seizures, partial seizures

side effects: hepatotoxicity, pancreatitis, thrombocytopenia, hyperammonemia, GI irritation, weight gain, ataxia, sedation, tremor
valproic acid
drug used for ADHD adn narcolepsy

side effects: hypertensino, tachyarrhythmia, Gille de la Tourette's syndrome, seizure, psychotic disorder with prolonged use, restlessness, dysphoric mood, rebound fatigue, addiction potential, loss of appetite, irritability, erectile dysfunction

contraindicaitons: advanced cardiovascular disease, glaucoma, hyperthyroidism, MAOI therapy, severe hypertension
amphetamine and methylphenidate