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36 Cards in this Set

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  • Back
Vitamin Definition
Required for normal metabolic function, not synthesized by the body, must be supplied from exogenous source
Causse of vitamin deficiencies
-Inadequate Intake
-Disturbances in Abosorption
-Increased Tissue Requirements
-Drug Induced Deficiency
Causes of Inadequate vitamin intake
-Bad Diet
-Weight Loss
Causes of Disturbance in Absorption
-Liver/biliary disease
-Chronic Diarrhea
-Pernicious Anemia
-Sprue, GI disease
Causes of Increased tissue requirement
Causes of drug induced deficiency
-Antibiotics (Isoniazid, cycloserine -TB)
Which vitamins are most toxic?
Fat Soluble vitamins-They can accumulate in the body fat and build up to toxil levels.

Example-Vitamin A and D
Thiamine B1 Deficiency
BeriBeri symptoms
-Increased blood pyruvic acid and Lactic acid
-reduced blood transketolase

-Loss of appetite
-Peripheral Neuritis (dry beriberi)
-Cardiovascular problems (wet beriberi)
-Wernickes encephalopathy
-Korsakoffs psychosis
-visual problems
Populations at risk for Beriberi
-Renal Dialysis
-Chronic Febrile infections
-furosemide (long term diuretic)
-aids patients
-infants eating white rice
Thiamine B1 toxicity

-ha, insomnia, nausea, gi bleeding, pulmonary edema, resp distress, vascular collapse, death
Thiamine B1 Uses in therapy
Riboflavin B2
Component of FMN, FAD, Flavin nucleotides

Has coenzyme function
Thiamine B1
Cofactor for enzymes involved in decarboxylation and the pentose hexosemonophosphate shunt
Riboflavin B2 deficiency states
-sore throat
-angular stomatitis (raw corners of mouth)
-Ulceration of cornea
-Pigmentatin of iris
-peripheral neuropathy
People at risk for riboflavin B2 deficiency
-Biliary obstruction
-Esophageal cancer
-infants using UV light for bilirubin therapy-destroys riboflavin too
Riboflavin toxicity
Riboflavin uses in therapy
To treat deficiencies
-biliary obstruction
Riboflavin b2 drug interactions
Chlorpromazine (antipsychotic) and imipramine (antidepresint)
interfere with riboflavin conversion to FMN
Nicotinic Acid, Niacin B3
Coenzyme NAD, NADP
Niacin deficiency
Dermatitis (pellagra)

3d's of niacin deficiency
people at risk for niacin deficiency
-individuals who eat primarily corn (tryptophan-> nicotinic acid, corn is LOW in tryptophan)
-Debilitated patients
Niacin toxicity at low dose
Niacin toxicity at intermediat dose
gi Distress, pruritis
Niacin toxicity at high dose
liver toxicity, glucose intolerance, cardiac arrythmia, pigmented hyperkeratosis
Niacin uses in therapy
-Hartnups disease
Pyroxidine B6
-aminoacid metabolism
Pyroxidine B6 deficiency symptoms
-skin problems
Pyroxidine b6 drug interactions

use of these drugs requires B6 supplementation
Pyroxidine B6 toxicity
chronic-maybe peripheral neuropathy
B6 uses in therapy
-treat drug induced deficiency
-huntingtons chorea
-infants with convulsions
-sideroblastic anemia
-carpal tunnel syndrome
b6 interaction with FOLATE
may develop folate deficiency if taking large doses of b6
b6 interactions with levodopa
B6 increases PERIPHERAL metabolism of levadopa to dopamine, instead of CNS metabolism->decreased effects of lovodopa on treatment of parkinsons
B6 interactions with phenytoin/phenobarbital
Decreased serum levels of these anticonvulsive drugs, buy up to 50%
Pantothenic Acid B5 Uses in therapy
-Treat other B vitamin deficiency
-Wound healing
-Decreased postoperative abdominal distention
Pantothenic Acid drug interactions