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22 Cards in this Set
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- Back
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cytotoxic agent used for solid organ transplantation, lupus nephritis, rheumatoid arthritis, pemphigus
side effects: hypertension, peripheral edema, GI hemorrhage, leukopenia, increased risk infection, lymphoma, GI disturbance, headache contraindications: hypersensitivity to polysorbate 80 (IV) |
Mycophenolic acid and mycophenolate mofetil
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cytotoxic agent used for rheumatoid arthritis
side effects: hypertension, hepatotoxicity, interstitial lung disease contraindications: pregnancy |
leflunomide
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lymphocyte signalling inhibitor used for keratoconjunctivitis sicca
side effects: nephrotoxicity, hypertension, neurotoxicity, hepatotoxicity, infection, gingival hyperplasia, hyperlipidemia, hirsuitism, GI disturbance contraindications: active ocular infection |
cyclosporine
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lymphocyte signalling inhibitor used for organ transplantation and atopic dermatitis
side effects: nepthrotoxicity, hypertensino, prolonged QT interval, hyperglycemia, lymphoma, infection, alopecia, GI disturbance, anemia, leukocytosis, thrombocytopenia, headache, insomnia, paresthesia, tremor, skin irritation contraindications: hypersensitivity to hydrogenated castor oil (IV) |
Tacrolimus
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lymphocyte signaling inhibitor used for organ transplantation and coronary artery disease
side effects: hypertensino, peripheral edema, throboembolic disorder, hyperlipidemia, hepatotoxicity, anemia, thrombocytopenia, arthralgia, asthenia, headache |
strolimus
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tumor necrosis factor alpha inhibitor used for rheumatoid arthritis, juvenile rheumatoid arthritis, psoriasis, psoritic arthritis, ankylosing spondylitis
side effects: myelosuppression, HF, optic neuritis, reactivation of TB, increased risk infection, demyelinating disease of CNS, injection site reaction, URI, ab pain, vomiting contraindciation: sepsis and HF |
Etanercept
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TNF-alpha inhibitor used for rheumatoid arthritis, crohn's disease(I), UC (I), ankylosing spondylitis (I), psoriatic arthritis (a)
side effects: myelosuppression, HF, optic neuritis, reactivation of TB, increased risk infection, demyelinating disease of CNS, injection site reaction, URI, ab pain, vomiting contraindications: sepsis, HF |
infliximab and adalimumab
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IL-1 inhibitor used for rheumatoid arthritis
side effects: neutropenia and increased risk infection contraindications: hypersensitivity to E. coli derived proteins |
anakinra
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globulin used for organ transplantation
side effects: cytokine release syndrome, hypertension, anemia, leukopenia, thrombocytopenia, increased risk infection contraindication: acute viral illness, history of allergy or anaphylaxis to rabbit protein |
antithymocyte globulin
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Ab used for organ transplant
side effects: cytokine release syndrome, hypertension, anemia, leukopenia, thrombocytopenia, increased risk infection contraindications: anti-mouse Ab greater than 1:1000, HF, seizure, pregnancy/breastfeeding, uncontrolled hypertension |
OKT3
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Ab's used for organ transplant
side effect: cytokine release syndrome, hypertension, anemia, leukopenia, thrombocytopenia, increased risk infection |
daclizumab and basiliximab
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Ab used for B-cell chronic lymphocytic leukemia
side effects: cytokine release syndrome, hypertension, anemia, leukopenia, thrombocytopenia, increased risk infection contraindications: active systemic infection, underlying immunodeficiency |
alemtuzumab
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Ab used for psoriasis
side effects: cytokine release syndrome, hypertension, anemia, leukopenia, thrombocytopenia, increased risk infection contraindications: HIV infection, low CD4 Tcell count |
Alefacept
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inhibitor of costimulation used for rheumatoid arthritis refractory to methotrexate or TNF-alpha inhibitors
side effects: exacerbation of COPD, increased susceptibility of infection, nausea, headache, urinary tract infection |
abatacept
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blockade of cell adhesion used for chronic plaque psoriasis
side effects: increased risk of serious infection, immune mediated thrombocytopenia, immune mediated hemolytic anemia, influenza-like symptoms, acne, lymphocytosis, elevated alkaline phosphatase, Ab formation |
efalizumab
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blockade of cell adhesion used for MS
side effects: cholelithiasis, progressive multifocal leukoencephalopathy, depression, pneumonia, rash, arthralgia, headache, fatigue, UTI, LRI contraindications: history PML or existing PML |
natalizumab
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investigational inhibitor of complement activation for treatment paroxysmal nocturnal hemoglobinuria
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eculizumab
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investigational close structural congener of abatacept that has increased affinity for B7-1 and B7-2
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belatacept
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inhibitor of purine metabolism used for immunosuppresion in renal transplantation, RA, IBD
side effects: pancreatitis, myelosuppression, hepatotoxicity, infection, gastritis contraindication: pregnancy |
azathioprine
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alkylating agent used for autoimmune diseases, leukemias and lymphomas, advanced mycosis fungoides, neuroblastoma, ovarian cancer, retinoblastoma, breast cancer, malignant histiocytosis
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cyclophosphamide
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drugs used for inflammatory conditions in many different organs, autoimmune diseases, replacement therapy for primary and secondary adrenal insufficiency
side effects: immunosuppression, cataracts, hyperglycemia, hypercortisolism, depression, euphoria, osteoporosis, growth retardation, muscle atrophy, impaired wound heling, hypertension, fluid retention contraindication: fungal infection |
prednisone, predinisolone, methylprednisolone, dexamethsone
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drug used for psoriasis, RA, other autoimmune disease
side effects: myelosuppression, liver failure, GI hemorrhage, mucous membrane inflammation, hepatic cirrhosis, kidney disease, interstitial pulmonary disease, hyperuricemia, GI disturbance, stomatitis, alopecia, photosensitivity, rash contraindications: pregnancy, breastfeeding, patients with psoriasis/RA alcoholics, alcholic liver disease, chronic liver disease, preexisting blood dyscrasia, immunodeficiency syndrome |
methotrexate
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