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23 Cards in this Set
- Front
- Back
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what is the direct stimulator and inhibitor of growth hormone release from the anterior pituitary
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stimulator – growth hormone releasing hormone
inhibitor – somatostatin |
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what hormone causes the epiphyseal plates on long bones to fuse?
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estrogen
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what does excess growth hormone during childhood cause?
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gigantism
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what does excess growth hormone during adulthood cause?
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Acromegaly
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What is the target tissue product of growth hormone?
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Insulin-like growth factor-1 (IGF-1)
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What causes a primary growth hormone deficiency type of disease?
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failure of cells to release IGF-1 in response to growth hormone
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What is mecasermin
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human recombinant IGF-1
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What is somatotropin
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human recombinant growth hormone
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What agent is most useful for growth failure in children with severe primary IGF-1 deficiency
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mecasermin
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What agent is most useful for AIDS associated wasting?
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somatotropin
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What agent is most useful for hypopituitary dwarfism?
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somatotropin
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Which drug can cause intracranial hypertension, scoliosis during rapid growth, and hypothyroidism
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somatotropin
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Why do you need to take mecasermin with meals?
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otherwise it might cause hypoglycemia
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What is octreotide?
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Somatostatin analogue
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What is bromocriptine
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dopamine agonist
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List 2 drugs that will decrease growth hormone secretion to treat acromegaly?
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octreotide, bromocriptine
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what are the main side effects of octreotide?
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GI problems, gallstones, Vitamin B12 deficiency
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What is lutropin
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Recombinant human luteinizing hormone
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What is urofollitropin and follitropin
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follicle stimulating hormone (urine derived or recombinant derived)
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What is the purpose of using lutropin and follitropin in women with polycystic ovary disease?
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part of the treatment for anovulation – to induce follicle maturation before ovulation
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What is the purpose of using human chorionic gonadotropin in women with polycystic ovary disease?
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part of the treatment for anovulation – to mimic the LH surge and induce ovulation
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What role does lutropin and urofollitropin play in the male?
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Stimulate spermatogenesis in males with hypogonadotropic hypogonadism
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compare the use of bromocriptine in the treatment of acromegaly and hyperprolactinemia
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acromegaly – high doses inhibits the release of growth hormone
hyperprolactinemia – inhibits prolactin secretion from prolactin producing pituitary adenomas |
