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24 Cards in this Set
- Front
- Back
Imipramine
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TCA
Advantages: cheap works with SSRI nonresponders Disadvantage: SE, cardiotoxicity, costly blood tests, delayed onset |
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Clomipramine
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TCA
Advantages: cheap works with SSRI nonresponders Disadvantage: SE, cardiotoxicity, costly blood tests, delayed onset |
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Phenylzine
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MAOI
Adv: Works in non-responders Dis: SE, orthostatic hypertension, weight gain, sexual dysfunction, dietary restrictions, overdose potential |
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Tranylcypromine
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MAOI
Adv: Works in non-responders Dis: SE, orthostatic hypertension, weight gain, sexual dysfunction, dietary restrictions, overdose potential |
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SSRI's
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Fluoxetine, Fluvoxamin, Citalopram, Escitalopram, Sertraline, Paroxetine
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SSRI's and treatment of anxiety?
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First line defense, Paroxetine and sertraline FDA approved and the others show efficacy
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SSRI advantages for treatment of anxiety?
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Favorable SE profile, broad spectrum, low abuse potential
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SSRI disadvantages for treatment of anxiety?
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Restlessness, jitteriness, increased anxiety on initial dosing, delayed onset of action
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Venlafaxine
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SNRI, generally efficacious in pain disorders
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Nefazodone
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Serotonin Antagonist
can cause liver failure |
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Mirtazapine?
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alpha2 antagonist
Effective for anxiety but causes sedation and weight gain |
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Benzodiazepine Advantages for treatment of anxiety?
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Highly efficacious, Rapidly acting, good SE
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Benzodiazepine Disadvantages for treatment of anxiety?
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Potential for abuse, withdrawal syndromes, sedation in elderly, short-term memory impairment
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Buspirone?
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5HT1a agonist
Anti-anxiolytic but not for panic disorders |
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Beta blockers for treatment of anxiety?
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Reduce somatic symptoms, for performance anxiety
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First Line for Panic D/O?
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Paroxetine, sertraline
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First Line for GAD?
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Buspirone +/- Benzo
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First Line for PTSD?
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Paroxetine, sertraline
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First Line for OCD?
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SSRI's
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First Line for social Phobia?
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Paroxetine, sertraline
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First Line for Performance anxiety?
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Beta-blocker
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Metabolic changes in elderly?
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decrease hepatic/renal function, decrease absorption, increased distribution, decreased protein binding, may need to use lower doses
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Metabolic changes in pregnancy?
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weigh risks, benefits and Tx alternatives, consider non-pharmacoloical therapies
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Considerations with sexually active when treating anxiety?
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Sexual dysfunction with SSRI's
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