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21 Cards in this Set
- Front
- Back
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Parkinsons
Name drugs |
Dopamine agonist (Balsa)
MAO inhibitors Antimuscarinics COMT inhibitors |
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Parkinsons--
Dopamine agonists--Name |
BALSA:
Bromocriptine, Amantadine, Levodopa, Selegiline, Antimuscarinics |
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Parkinsons-L dopa/carbidopa: family
MOA |
Dopamine agonists
increase level of dopamine in brain can cross BBB, converted to dopamine by dopa decarboxylase in CNS |
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Parkinsons-L dopa/carbidopa
SE |
Arrythmias from peripheral conversion.
Carbidopa is a peripheral decarboxylase inhibitor that is given with L dopa to increase the bioavailability of L dopa in hte brain and limit the peripheral side effects. Dyskinesias can also occur |
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Selegiline:
used for family |
Pakinsons
MAO inhibitor |
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Selegiline:
MOA CLinical use |
selectively inhibits MAO-B thereby increases availability of dopamine
Clinical use--Adjunctive agent to L dopa in treatment of parkinsons |
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Selegiline-- SE
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May enhance adverse effects of L dopa
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Sumatriptan:
used for Mechanism |
Parkinsons
5-HT(1D) agonist. Half life <2 hours |
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Sumatriptan--
Clinical use |
Acute migraine, cluster headache attacks
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Sumatriptan:
SE |
chest discomfort, mild tingling,
contraindicated: pts with CAD, Prinzmetals angina |
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Epilepsy drugs--
names: |
benzodiazepines, Carbamazepine, Ethosuximide, Phenobarbital, Phenytoin, Valproic acid, Lamotrigine, Gabapentin, Topiramate
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Benzodiazepines:
used for MOA SE |
Epilepsy
increased action of GABA(A) Sedation, tolerance, dependence |
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Carbamazepine
used for MOA Tox/SE |
epilepsy
increased Na channel inactivation Diplopia, ataxia, induction of P450, blood dyscrasias (agranulocytosis, aplastic anemia)liver tox ( always check LFT) |
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Ethosuximide:
used for MOA SE |
Epilepsy
blocks thalamic T type Ca channels GI distress, lethargy, HA, urticaria, Steven Johnson syndrome |
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Phenobarbital:
used for MOA SE |
epilepsy
increased GABA (A) action Sedation, induction of P450, tolerance, dependence |
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Phenytoin:
used for MOA |
Grand mal seizures, Epilepsy. Also, Class IB antiarrythmic
Use dependent blockade of Na channels |
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Phenytoin: SE
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Nystagmus, ataxia, diplopia, lethargy
Chronic use causes gingival hyperplasiain children, peripheral neuropathy, hirsutism, megaloblastic anemia (dec. B12),and malignant hyperthermia teratogenic--fetal hydantoin syndrome |
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Valproic acid:
used for MOA SE |
Epilepsy
Increased Na channel inactivation, increased GABA concentration GI distres, hepatotoxicity ( rare but fatal so measure LFT), neural tube defects in fetus (spina bifida) |
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Lamotrigine--
used for MOA SE |
epilepsy
Blocks voltage gated Na channels Life threatening rash, Steven Johnson rash |
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gabapentin:
used for MOA SE |
Epilepsy
increased GABA release Sedation, movement disprders |
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Topiramate:
used for MOA SE |
Epilepsy
Blocks Na channels,increases GABA action Sedatione, mental dulling, kidney stones, weight loss |
