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21 Cards in this Set

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Parkinsons
Name drugs
Dopamine agonist (Balsa)
MAO inhibitors
Antimuscarinics
COMT inhibitors
Parkinsons--
Dopamine agonists--Name
BALSA:
Bromocriptine, Amantadine, Levodopa, Selegiline, Antimuscarinics
Parkinsons-L dopa/carbidopa: family
MOA
Dopamine agonists
increase level of dopamine in brain
can cross BBB, converted to dopamine by dopa decarboxylase in CNS
Parkinsons-L dopa/carbidopa
SE
Arrythmias from peripheral conversion.
Carbidopa is a peripheral decarboxylase inhibitor that is given with L dopa to increase the bioavailability of L dopa in hte brain and limit the peripheral side effects.

Dyskinesias can also occur
Selegiline:
used for
family
Pakinsons
MAO inhibitor
Selegiline:
MOA
CLinical use
selectively inhibits MAO-B thereby increases availability of dopamine

Clinical use--Adjunctive agent to L dopa in treatment of parkinsons
Selegiline-- SE
May enhance adverse effects of L dopa
Sumatriptan:
used for
Mechanism
Parkinsons

5-HT(1D) agonist. Half life <2 hours
Sumatriptan--
Clinical use
Acute migraine, cluster headache attacks
Sumatriptan:
SE
chest discomfort, mild tingling,

contraindicated: pts with CAD, Prinzmetals angina
Epilepsy drugs--
names:
benzodiazepines, Carbamazepine, Ethosuximide, Phenobarbital, Phenytoin, Valproic acid, Lamotrigine, Gabapentin, Topiramate
Benzodiazepines:
used for
MOA
SE
Epilepsy

increased action of GABA(A)

Sedation, tolerance, dependence
Carbamazepine
used for
MOA
Tox/SE
epilepsy
increased Na channel inactivation

Diplopia, ataxia, induction of P450, blood dyscrasias (agranulocytosis, aplastic anemia)liver tox ( always check LFT)
Ethosuximide:
used for
MOA
SE
Epilepsy
blocks thalamic T type Ca channels
GI distress, lethargy, HA, urticaria, Steven Johnson syndrome
Phenobarbital:
used for
MOA
SE
epilepsy
increased GABA (A) action
Sedation, induction of P450, tolerance, dependence
Phenytoin:
used for
MOA
Grand mal seizures, Epilepsy. Also, Class IB antiarrythmic

Use dependent blockade of Na channels
Phenytoin: SE
Nystagmus, ataxia, diplopia, lethargy
Chronic use causes gingival hyperplasiain children, peripheral neuropathy, hirsutism, megaloblastic anemia (dec. B12),and malignant hyperthermia

teratogenic--fetal hydantoin syndrome
Valproic acid:
used for
MOA
SE
Epilepsy
Increased Na channel inactivation, increased GABA concentration

GI distres, hepatotoxicity ( rare but fatal so measure LFT), neural tube defects in fetus (spina bifida)
Lamotrigine--
used for
MOA
SE
epilepsy
Blocks voltage gated Na channels

Life threatening rash, Steven Johnson rash
gabapentin:
used for
MOA
SE
Epilepsy
increased GABA release
Sedation, movement disprders
Topiramate:
used for
MOA
SE
Epilepsy
Blocks Na channels,increases GABA action

Sedatione, mental dulling, kidney stones, weight loss