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34 Cards in this Set

  • Front
  • Back
what lobe/zone is most often involved in prostatic cancer?
posterior lobe, peripheral zone
what is a common site of metastases for prostate cancer?
what are useful tumor markers for prostate CA
psa, and prostatic acid phosphatase
this type of skin cancer has palisading nuclei
basal cell carcinoma
dyplastic nevi are a precursor fot this type of cancer
this type of skin cancer is associated with keratin pearls
squamous cell carcinoma of skin
the translocation 11;22 is associated with this cancer of the bone that occurs most commonly in young boys
ewing's sarcoma
this tumor is characterized by a "double bubble" or "soap bubble" appearance
benign giant cell tumor
this is the most common benign bone tumor, usually in men younger than 25, with a rare transformation to malignancy
Most common adult brain tumor?
Glioblastoma multiforme (grade IV astrocytoma) See pseudopalisading tumor cells, central necrosis and hemorrhage.
Second most common adult tumor?
Meningioma, occurring in convexities of hemispheres and parasagittal region. See psammoma bodies.
Benign, slow-growing tumor in frontal lobes?
Oligodendroglioma, look for fried egg appearance, often calcified.
Third most common tumor, often localized to CN8?
Schwannoma, see it in acoustic Schwannoma. Antoni A (compact) and Antoni B (loose) patterns.
Most common forms are prolactin-secreting?
Pituitary Adenoma, which derives from Rathke's Pouch and can produce secondary bitemporal hemianopsia and hypopituitarism
Primary Brain Tumors-Child Peak Incidence: Highly malignant cerebellar tumor?
Medulloblastoma, can compress 4th ventricle and cause hydrocephalus. See rosettes or pseudorosettes.
Primary Brain Tumors-Child Peak Incidence: Cerebellar tumor associated with von Hippel-Landau syndrome?
Hemangioblastoma, see foamy cells and high vascularity, can produce excess EPO-->polycythemia.
Primary Brain Tumors-Child Peak Incidence: Commonly found in fourth ventricle, causing hydrocephalus?
Ependyomomas, which have perivascular rosettes and rod-shaped blepharoblasts near nucleus on exam.
Primary Brain Tumors-Child Peak Incidence: Diffusely infiltrating glioma, usually found in posterior fossa?
Low-grade Astrocytoma
Primary Brain Tumors-Child Peak Incidence: Benign tumor often confused with pituitary adenoma?
Craniopharyngioma, which also is derived from Rathke's pouch, also presents with bitemporal hemianopsia, also calcified.
To Brain?
Lung, Breast, Skin (melanoma), Kidney (renal cell carcinoma), GI. Lots of Bad Stuff Kills Glia. 50% of brain tumors are due to metastases.
To liver?
Colon>Stomach>Pancreas>Breast>Lung. Cancer Sometimes Penetrates Benign Liver. Metastases much more common than primary liver tumors.
To bone?
Breast, lung, thyroid, testes, kidney, prostate.=> "BLT with a Kosher Pickle."
Most common organ receiving metastases?
Adrenal medulla, then cortex.
Most common organ sending metastases?
Paraneoplastic effects of tumors: Cushing's Syndrome
ACTH/ACTH-like peptide from small-cell lung CA
Paraneoplastic effects of tumors: SIADH
ADH/ANP from small cell lung CA and intracranial neoplasms.
Paraneoplastic effects of tumors: Hypercalcemia
PTH-related peptide/TGF-alpha/TNF-Alpha/IL-2 from squamous cell lung CA, renal cell CA, Breast CA, multiple myeloma, bone metastasis.
Paraneoplastic effects of tumors: Polycythemia
EPO from renal cell CA.
Paraneoplastic effects of tumors: Lambert-Eaton Syndrome
Antibodies against presynaptic Ca2+ channels at NMJ, generated by Thymomas and bronchogenic CA.
Paraneoplastic effects of tumors: Gout
Hyperuricemia due to excess nucleic acid turnover, found in various neoplasms.
Cancer Epidemiology Male incidence?
Prostate(32%)>Lung(16%)>Colon and Rectum (12%)
Cancer Epidemiology Male Mortality?
Cancer Epidemiology Female incidence?
Breast (32%)>Lung(13%)>Colorectal(13%)
Cancer Epidemiology Female Mortality?