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7 Cards in this Set
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- Back
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Methotrexate (Trexall, Rhematrex)
Class, MOA, Uses, SEs? |
Methotrexate (Trexall, Rheumatrex)
Class: DMARDs-Non Biologic; Musculoskeletal Antirheumatics MOA: Inhibits cells in S phase by inhibiting dihydrofolate reductase; inhibits T cell proliferation, reduce B & T cell activity Uses: Tx cancer, severe rheumatoid arthritis SEs: Hepatic fibrosis, GI ulceration, bone marrow suppression |
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Sulfasalazine (Azulfidine)
Class, MOA, USes, SEs? |
Sulfasalazine (Azulfidine)
Class: DMARDs-Non Biologic; Musculoskeletal Antirheumatics MOA: Anti-inflammatory effects Uses: Tx rheumatoid arthritis unresponsive to NSAID and inflammatory bowel disease SEs: Pregnancy category B, N/D/V, anorexia, headache, rash, GI and dermatological effects |
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Leflunomide (Arava)
Class, MOA, USes, SEs? What is unique about its metabolite? |
Leflunomide (Arava)
Class: DMARDs-Non Biologic; Musculoskeletal Antirheumatics MOA: Inhibits pyrimidine synthesis and limits lymphocyte proliferation and reduces inflammation Uses: Rheumatoid Arthritis SEs: Hepatotoxic, potent suppression of immune system increase risk of infection, pregnancy category X Other: Active metabolite is responsible for anti-inflammatory effects |
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Hydroxycholorquine (Plaquenil)
Class, MOA, USes, SEs? What is important about it's duration? |
Hydroxycholorquine (Plaquenil)
Class: DMARDs-Non Biologic; Musculoskeletal Antirheumatics MOA: Inhibits the rheumatoid factor Uses: Tx of severe rheumatoid arthritis in conjunction with other drugs; Antimalarial agent SEs: Retinal Damage Duration: longer onset of action (3-6 months) |
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Entanercept (Enbrel)
Infliximab (Remicade) Adalimumab (Humira) Class, MOA, USes, SEs? Routes? |
Entanercept (Enbrel)
Class: DMARDs-Biologic TNF-a Antagonist; Musculoskeletal Antirheumatics MOA: Prevents TNF-a (tumor necrosis factor- inflammation modulator) from interacting with its receptor Uses: Decrease progression of rheumatoid arthritis that is moderate to severe; Tx psoriatic arthritis, active ankylosing spondylitis, and crohn’s disease SEs: erious infections (TB and fungal infections), upper respiratory tract infections, rhinitis Route: Entanercept (Enbrel) and Adalimumab (Humira) are IM Infliximab (Remicade) is SubQ |
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Rituximab (Rituxan)
Class, MOA, Uses, SE? |
Rituximab (Rituxan)
Class: DMARDs-Biologic B-lymphocyte depleting agents; Musculoskeletal Antirheumatics MOA: Forms a complex on the surface of B-lymphocytes, targeting them for destruction by the immune system Uses: Moderate to severe Active Rheumatoid arthritis SEs: Progressive multifocal leukoencephalopathy, bronchospasm, arrhythmias, hypotension, mucocutaneous skin reactions, hyperglycemia, anemia, back pain, anaphylaxis, angioedema |
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Abatacept (Orencia)
Class, MOA, Uses, SE? |
Abatacept (Orencia)
Class: DMARDs-Biologic T-cell activation inhibitors; Musculoskeletal Antirheumatics MOA: Prevents antigen presenting cells from fully activating T-lymphocytes Uses: Reduce S/S of moderate to severe active rheumatoid arthritis in adults SEs: Increased risk of infection |
