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19 Cards in this Set
- Front
- Back
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What is the mechanism of action for NMB's?
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competitive antagonist of the nAChR in the NMJ
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What is the sequence of paralysis when using NMB's?
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Face--->Diaphragm (fine tactile -----> large slow moving)
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What would happen if you administered an AChE inhibitor alongside a NMB?
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negate the effects (AChE competes w/ NMB)
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Do NMB's enter the CNS?
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no
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Which NMB is depolarizing?
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Succinylcholine
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What is the mechanism of action of Succinylcholine?
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acts like a long acting ACh
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How is succinylcholine metabolized?
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butyrylcholinesterase in plasma and liver
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What is the end result of prolonged depolarization at the NMJ?
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flaccid paralysis
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Will neostigmine reverse the effects of succinylcholine phase I blocking?
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no (it is an AChE inhibitor, will have no effect on succinylcholine)
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Will neostigmine reverse the effects of succinylcholine phase II blocking?
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possibly (receptors are gradually repolarized)
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Mivacurium and succinylcholine are _______ acting NMB's
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short
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Vecuronium, Rocuronium, Cistatracurium and Atracurium are __________ acting NMB's
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intermediate
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Tubocurarine and Pancuronium are _______ acting NMB's
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long
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What are the adverse effects of non-depolarizing NMB's (3) ?
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Histamine release, block autonomic ganglia, block muscarinic receptors
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What effect can histamine have on CV system?
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hypotension
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What can histamine release cause regarding the lungs?
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bronchoconstriction
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What effect can muscarinic blockade have on CV system?
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tachychardia
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succinylcholine has what effect on K+?
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K+ efflux (hyperkalemia)
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What is the cause of malignant hyperthermia?
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Excessive Ca+ release triggered by anesthetics and succinylcholine
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