Pharmacology Maloney Autonomics

Front 1

the adrenal medulla mainly releases __________

Back 1

epinephrine

Front 2

__________ is the enzyme that converts NE to Epi in the adrenal medulla

Back 2

PNMT

Front 3

does epi or norepi bind better to beta2 receptors?

Back 3

epi

Front 4

Epi in low doses _______ PVR, and _________ PVR in high doses

Back 4

decreases, increases

Front 5

ACh diffuses into the blood stream where it is broken down into Choline and acetate by the enzyme ____________

Back 5

Butyryl Cholinesterase

Front 6

______________ is released from parasympathetic nerve terminals and binds to ______ and ________ receptors

Back 6

ACh; M and N

Front 7

What is the main method for ACh inactivation?

Back 7

Acetylcholinesterase located in synaptic cleft

Front 8

Where are N receptors?

Back 8

PS ganglia, S ganglia, Skeletal m.

Front 9

Where are M receptors located?

Back 9

glands, smooth m., organs (heart, kidney, intestines, etc)

Front 10

G___ activates adenyl cyclase

Back 10

s

Front 11

G__ inhibits adenylyl cyclase

Back 11

i

Front 12

G__ activates phospholipase Cbeta

Back 12

q

Front 13

alpha1 receptors are associated with which G-protein?

Back 13

Gq

Front 14

PLCbeta activation causes _______ IP3, _______ PKC and ______ Ca2+

Back 14

increased; increased; increased

Front 15

What effect do alpha1 agonists have on BP?

Back 15

increase

Front 16

alpha2 receptors are associated with which G-protein?

Back 16

Gi

Front 17

alpha2 receptor agonists have what effect on neurotransmitter release? K+ permeability?

Back 17

decrease; increase

Front 18

beta receptors are associated with which G-protein?

Back 18

Gs

Front 19

What is the effect of beta1 receptor agonists on kidneys and heart?

Back 19

increased renin release; increased HR and force of contraction

Front 20

What is the effect of beta2 receptor agonists on smooth m. and liver?

Back 20

relaxation; glycogenolysis/gluconeogenesis

Front 21

What is the effect of beta3 receptors on adipose tissue?

Back 21

lipolysis

Front 22

M3 receptors are located on _______ and ___________ and activate G_____

Back 22

smooth m; secretory glands; q

Front 23

Where are M2 receptors located? Which G-protein do they activate?

Back 23

heart; Gi

Front 24

chronic exposure to an antagonist causes receptor ___________

Back 24

upregulation

Front 25

What are two ways to induce mydriasis using autonomic mimetics?

Back 25

Block M receptors, Activate alpha1 receptors

Front 26

What type of autonomic receptors are on the ciliary m.?

Back 26

M3

Front 27

m receptor agonists cause the ciliary m. to __________ allowing for ________ vision

Back 27

contract; near

Front 28

What would you give to a patient to dilate the pupil and avoid the effect of blurry vision?

Back 28

alpha1 agonist

Front 29

What endogenous catecholamine is most likely to bind to beta2 receptors on the lungs?

Back 29

Epi

Front 30

What type of M receptors are found in the lungs? what effects do their agonists have?

Back 30

M3; bronchoconstriction and mucus secretion

Front 31

What type of drug would be considered a physiological antagonist of bronchoconstriction?

Back 31

B2 agonist

Front 32

M3 receptor agonists in the stomach cause what?

Back 32

acid secretion

Front 33

Which receptors are activated to cause detrusor m. contraction?

Back 33

M

Front 34

Which receptors are activated to cause urinary sphincter constriction?

Back 34

alpha1

Front 35

stimulation of _____ causes ejaculation

Back 35

alpha1

Front 36

__________ stimulation causes erection

Back 36

parasympathetic

Front 37

Activation of M3 receptors on endothelial walls results in?

Back 37

NO release and vasodilation

Front 38

What effect does parasympathetic activation have on PVR?

Back 38

none

Front 39

liver and skeletal m. blood vessels have mainly ____ adrenergic receptors

Back 39

beta2

Front 40

Parasympathetic stimulation to the heart _________ HR, _________ force of contraction (atrial) and ________ conduction velocity

Back 40

decrease; decrease; decrease

Front 41

Sympathetic stimulation to the heart activates beta__ receptors

Back 41

1

Front 42

Stimulation of which type of receptor will produce the greatest increase in cardiac output?

Back 42

beta1

Front 43

What is one of the most bothersome side effects of blocking muscarinic receptors?

Back 43

dry mouth

Front 44

What may be a consequence of blocking beta receptors in a diabetic?

Back 44

impair response to hypoglycemia

Front 45

activation of alpha2 receptors on pancreas ________ insulin release

Back 45

decreases

Front 46

activation of beta2 receptors on skeletal m. shifts K+ _______ the cell

Back 46

into