Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
Cholinesterase Inhibitor
-MOA? |
-Produce reversible or irreversible inhibition of ChE activity
-Like muscarinic agonists but additional Nn and Nm effects plus some CNS effects for some |
|
|
Reversible ChE-I
-2 subcategories |
-Short acting (mins)
-Long acting (3-4 hours) |
|
|
Irreversible ChE-I
|
-Long acting
-Organophosphates |
|
|
Effect of ChE-I
-Eye (2) |
-Miosis (constriction)
-Paralysis of accommodation |
|
|
Effects of ChE-I
-GI tract (2) |
-Stimulation
-Contractions |
|
|
Effects of ChE-I
-Bladder (1) |
-Stimulation of urination
|
|
|
Effects of ChE-I
-Glands (5) |
-Tearing
-Nasal Secretions -Salivation -Sweating -Increase in bronchial secretions |
|
|
Effects of ChE-I
-Skeletal Muscle (1) |
-Contractions
|
|
|
Effects of ChE-I
-Ganglion (1) |
-Stimulation
|
|
|
Reversible ChE-I agents
(3) |
-Physostigmine
-Neostigmine -Edrophonium (short acting) |
|
|
Irreversible ChE-I agents (1)
|
-Echothiophate (no CNS)
|
|
|
Uses for ChE-I
(8) |
-Open angle Glaucoma
-Paralytic Ileus -Myasthenia gravis -Dry mouth (xerostomia) -Atropine toxicity -Anethesia -Paroxysmal Atrial Tachycardia (PAT) -Alzheimer's disease |
|
|
Myasthenia gravis and ChE-I
-Uses -Medication used? |
-Used in treatment and diagnosis
-Edrophonium |
|
|
Anesthesia and ChE-I
-MOA? |
-Reversal of NMJ block
|
|
|
Types of Organophosphate ChE-I
(2) |
-Nerve gases (war and terrorism)
-Insecticides |
|
|
Features of Organophosphate ChE-I
(2) |
-Volatile
-Lipid Soluble |
|
|
Symptoms of Organophosphate ChE-I depends on?
|
-Route Dependent
-Topical versus Oral |
|
|
Treatment of Organophosphate ChE-I
(2) -Medications used (2) |
-Muscarinic Blockade--Atropine
-Enzyme regeneration--Pralidoxime (2PAM) |
|
|
Donepezil
-MOA? -Uses (1) |
-ChE-I
-Non-competitive -Reversible -Selectivity for AchE in CNS -Long half life (70 hours) -Used to treat Alzheimer's disease -No hepatotoxicity reported |
|
|
Donepezil
-Effectiveness? |
-Mild to moderate patients see modest improvement in neuropsych tests and assessment of activities if life
-Helpful but not therapeutic |
