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5 Cards in this Set
- Front
- Back
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describe how you can have pharmacokinetic & pharmacodynaic phenotypes?
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- pharmacokinetics: difference in how body is metabolizing drug (transporters or metabolizing enzymes)
- pharmacodynamics: difference in how drug is acting on body (receptors or targets) |
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what happens in clopidogrel (plavix) when someone expresses a variant of CYP450 2C19*3?
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- it is a prodrug so it cannot be activated and it doesn't work as well
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what happens to coedine if you're overexpressing CYP450 2D6?
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- get too much morphine, could even develop toxicity
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_____ which inactivates warfarin can be over/under expressed & mess with metabolism. _____ which warfarin binds to does what?
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- CYP2C9
- VKORC --> turns vit K epoxide --> vit K to allow for prothrombotic activities |
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why do you have to test for cetuximab (erbitux) & trastuxumab (herceptin)?
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- have to test for EGFR & HER2/neu gene to make sure it will actually respond to that cancer
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