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10 Cards in this Set
- Front
- Back
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triggers of ulcers
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H.pylori
NSAIDs pancreatic tumor Zollinger-Ellison syndrome Cushing's ulcer GERD |
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Triggers for GERD
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smoking, caffeine, alcohol, stress
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Gastric secretion MOA (3)
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1. Histamine on ECL cells bind H2 -- incr cAMP -- PK-phos -- Phos-H+pump --> pumps H+ out K in
2. ACh binds M3 -- DAG -- Phos-PK --> H+ pump 3. Gastrin from blood binds CCK2 --> PLC --> Ca2+ -- Phos-PK --> H+ pump |
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misoprostol
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stimulates Prostaglandins - stimulates mucus and bicarb from epithelial cells
decr cAMP and decr H+ pump on parietal cell |
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Sucralfate
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coating agent
proves a protective layer on epithelial surface of gastric mucosa |
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PPI
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irreversible = noncomp
potent long acting slow onset of action pro-drug --- activated in acid conditions (forms sulfide bond) |
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H2RA
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short acting
fast acting less potent competitive reversible |
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5-HT receptor antag
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good for:
post op emesis; chemotherapy; |
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H1-RA
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preferred for motion sickness; post op emesis
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Anticholingerics -- antiemetic properties
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used for motion sickness
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