Pharmacology Iii Exam Ii

Front 1

A patient has HIV and you want to prescribe a drug that binds directly to the enzyme nucleotide-reverse transcriptase. Which is the DOC?

Back 1

Efavirenz

Hint 1

Remember this drug induces P450 CYP3A4
Teratogenic

Front 2

Which of the nucleotide reverse transcriptase inhibitors causes pancreatitis?

Back 2

Didanosine

Hint 2

Remember to shut off if lactic acidosis or hepatoxicity occurs

Front 3

I say Buffalo hump, abdominal fat, thin face, Stevens Johnson

Back 3

You say HIV Protease inhibitors, Ritonavir, Atazanavir, Tripranavir, Saquinavir

Hint 3

CYP3A4, increases bioavailability of other drugs.

Front 4

Which drug is the DOC for the HIV protease inhibitors?

Back 4

Atazenavir

Hint 4

No cross resistance,
Once a day administration
Less effect on lipoproteins

Front 5

Which drug binds to the gp41 subunit of the HIV viral envelope?

Back 5

Enfuvirtide

Hint 5

Fusion inhibitor, no cross resistance, given by subcutaneous injection.

Front 6

Which antifungal drug discussed is the DOC for systemic fungal infxns?

Back 6

Amphotericin B

Front 7

All of the Azoles effect the P450 system except for this one

Back 7

Fluconazole

Front 8

Which antifungal is the DOC for aspergillosis?

Back 8

Voriconazole

Front 9

Which antifungal is the best for CNS penetration when Amphotericin B has failed?

Back 9

Fluconazole

Front 10

Which of the antifungals causes gynecomastia

Back 10

Ketoconazole

Front 11

This drug interacts with ergosterol in the cell membrane of a fungus and is a pro-drug to another drug often used in cancer treatment

Back 11

Flucytosine converts to 5FU

Front 12

Which antifungal accumulates in the keratin and takes a long time to work?

Back 12

Griseofulvin

Front 13

Which of the OTC onychomycosis agents is known to be hepatotoxic?

Back 13

Terbinafine

Front 14

What is the name of the drug that blocks ergosterol synthesis and is used in vaginal candidiasis?

Back 14

Miconazole

Front 15

What is the DOC for thrush?

Back 15

Nystatin.

Front 16

Which drug do you give for Aspergillosis if Voriconazole has failed?

Back 16

Caspofungin

Front 17

This drug plus Amphotericin B produces supra-additive effects in certain infections

Back 17

Flucytosine

Front 18

Which one of the antifungals is known to be extremely nephrotoxic and possibly hepatoxic as well?

Back 18

Amphotericin B

Front 19

Which antifungal is known to cause significant bone marrow suppression and anemia

Back 19

Flucytosine

Front 20

Which antifungal causes porphyria?

Back 20

Griseofulvin

Front 21

I cause lymphocytes to lyse and have a very broad effect and should be given in a pulsatile fashion

Back 21

Prednisone

Front 22

I am a calcineurin inhibitor and cause gingival hyperplasia

Back 22

Cyclosporine

Front 23

I am the DOC for organ transplant maintenance and I also am known to cause significant insomnia.

Back 23

Tacrolimus

Front 24

I am the mammalian target of rhabdomycin and I block the T-cells from responding to IL-2

Back 24

Sirolimus

Front 25

I am a cell proliferation inhibitor and I am known to be severely toxic to bone marrow, causing anemia and leukopenia.

Back 25

Sirolimus

Front 26

I am famous for being able to put out a fire in the immune system after T-cells have already established a response to a foreign organ

Back 26

Cyclophosphamide

Front 27

I am selective for T & B cells and I inhibit purine synthesis enzyme inosine monophosphate dehydrogenase.

Back 27

Mycophenolate Mofetil

Front 28

I inhibit purine synthesis and am selective for T& B cells plus cause a severe rash as a side effect.

Back 28

Mycophenolate Mofetil

Front 29

Of the two drugs we need to know that target T cells and are calcinurin inhibitors, I should not be taken with grapefruit juice and you should monitor me if I am being taken with an ACE or ARB.

Back 29

Tacrolimus

Front 30

I block the production of TNF alpha and am a category X drug

Back 30

Thalidomide

Front 31

I am a calcineurin inhibitor which means I am selective for T-cells. I'm interesting because I should not be taken with food and am very neurotoxic

Back 31

Tacrolimus

Front 32

I am an antibody immuno suppressor and I block IL2 on activated T-cells, have an extremely long half life and am used in kidney transplants.

Back 32

Daclizumab/Basiliximab

Front 33

If you want to use me its a good idea to pre-treat with prednisone because I am known to cause cytokine release syndrome.

Back 33

Muromonab CD3

Front 34

I'm made from horses and rabbits and am an IgG antibody

Back 34

Lymphocyte immune Globulin (AtGam)

Front 35

I am used to treat relapsing and remitting Multiple sclerosis

Back 35

Beta Seron B1b

Front 36

If you use me to stimulate T-B-and NK cells I should be in the hospital because I am gonna have a ton of problems

Back 36

Interleukin-2

Front 37

You will want to get my help when a patient has renal cell carcinoma or malignant melanoma

Back 37

Interleukin 2

Front 38

I'm an immunomodulator and I cause significant blood clots and hypertension while I try to fix your anemia from chemo

Back 38

Epoetin

Front 39

You will want to use me when you have a Neutropenia from a stem cell transplant or chemo and man do I ever hurt your bones. You will hate me.

Back 39

G-CSF (Neupogen)

Front 40

I work on IL-11 and I prevent chemo induced thrombocytopenia so you won't need to give platelets. While I'm helpful in this respect I also cause fluid retention and have been known to cause a dilutional anemia.

Back 40

Oprelvekin

Front 41

I'm used to stimulate Macrophages, B-cells, T-cells, and NK cells plus I cause severe hypotension.

Back 41

Interleukin-2

Front 42

I'm a Calcineurin inhibitor and you will need to up my dose when you are taking phenytoin or rifampin because I share CYP3A with those guys.

Back 42

Cyclosporine

Front 43

If you are taking erythromycin, ketoconazole, grapefruit juice and verapamil you will need to decrease my dose because I inhibit CYP3A. Hint I am a calcineurin inhibitor.

Back 43

Cyclosporine

Front 44

M
A
C
Me
T
A
L
These drugs are in the immuno lecture and are absolutely contraindicated in pregnancy

Back 44

Mycophenolate Mofetil
Azathioprine
Cyclophosphamide
Methotrexate
Thalidomide
Leflunomide

Front 45

I inhibit viral uncloaking and am known to cause some dopaminergic CNS symptoms (hallucinations, psychosis, parkinsonian)

Back 45

Amantadine

Front 46

I am the DOC for influenza and I'm also a neuraminidase inhibitor.

Back 46

Oseltamivir

Front 47

I'm the neuraminidase inhibitor for nasal delivery and also cause a host of nasal and respiratory side effects and should not be given to COPD patients

Back 47

Zanamivir

Front 48

I'm the DOC for RSV and I am category X teratogenic

Back 48

Ribavirin

Front 49

I am the DOC for Herpes and I am a guanosine analogue that makes use of the viral thymidine kinase.

Back 49

Acyclovir/Valacyclovir

Front 50

I am OTC and I work on cold sores by not allowing viral fusion. Who am I?

Back 50

Docosanol/Abreva

Front 51

I work on CMV and Herpes and I'm a guanosine analogue that inhibits viral DNA polymerase.

Back 51

Ganciclovir/Valganciclovir

Front 52

This drug is given for resistant herpes/CMV via intravenous infusion and can be highly nephrotoxic, teratogenic and cause hypocalcemia.

Back 52

Foscarnet

Front 53

I cause terrible flu-like symptoms and am the DOC for Hep C given via PEG injection often with Ribavirin

Back 53

Interferon alpha 2b

Front 54

I am a reverse transcriptase inhibitor often given to HIV patients. I can also be used to fight Hep B and am a cytosine analogue often combined with zidovudine

Back 54

Lamivudine

Front 55

I am given with interferon to fight Hep C and am Category X teratogenic.

Back 55

Ribavirin

Front 56

I am often given for CMV/Herpes prophylaxis in transplant patients, immunocompromised or for CMV retinitis. I also cause a Neutropenia

Back 56

Ganciclovir

Front 57

I am an HIV nucleotide reverse transcriptase inhibitor that has been shown to cause pancreatitis.

Back 57

Didanosine

Front 58

I am a dTp analogue and I inhibit viral reverse transcriptase. I am given during pregnancy to HIV mothers to reduce possibility of transmission to the fetus.

Back 58

Zidovudine

Front 59

The category of HIV drugs that should be stopped immediately if lactic acidosis or hepatoxicity is noted.

Back 59

Nucleotide reverse transcriptase inhibitors

Front 60

I am the DOC for treatment of HIV in naive patients and am given with Emcitrabine. Plus I may make you fart and throw up.

Back 60

Tenofovir

Front 61

I am the DOC NON-nucleotide reverse transcriptase inhibitor and I induce CYP3A4 P450 system and am extremely teratogenic. (Category X)

Back 61

Efavirenz

Front 62

You might think I'm a corticosteroid from my buffalo hump, fat tummy, but NO! You are wrong! I am a category of drugs used to treat HIV.

Back 62

HIV Protease inhibitors

Front 63

I am the DOC HIV protease inhibitor and can be given once a day and have less lipid problems than others in my class

Back 63

Atazanavir

Front 64

I am an HIV protease inhibitor that really junks it up with the CYP34A system and shouldn't be taken with drugs like amiodarone or benzos or meperidine.

Back 64

Ritonavir

Front 65

I am the only HIV drug mentioned in class to Bind gp41 and serve as a Fusion inhibitor. Another cool thing about me is there seems to be no cross resistance to my magical pharmacological powers.

Back 65

Enfuvirtide (Fuzeon)