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14 Cards in this Set
- Front
- Back
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What two things are the basis of anti-herpes virus drugs?
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The coding of their own DNA polymerase
The coding of their own Thymidine Kinase |
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Name 3 key characteristics of the Herpes virus.
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Enveloped
dsDNA Latent virus |
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Cytomegalovirus causes enlargement of the infected cell and is generally asymptomatic. Immunosuppressed individuals however, may present with these symptoms.
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CMV retinitis
Overwhelming systemic infection |
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Epstein-Barr virus is generally asymptomatic until the second decade of life. It is consistent however with these two conditions.
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Burkitt's lymphoma
Nasal-pharyngeal carcinoma |
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Who is generally afflicted with Herpes virus 6?
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Children - rash - trivial
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Describe Herpes virus 7
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No disease associated with it
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Describe Herpes virus 8
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Kaposi Sarcoma - happens to elderly, more in mediterranean descent - one of two indicators of HIV appearance in population.
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What is acyclovir?
How does it work? |
The first anti-herpes drug
A Guanine nucleotide that is efficiently phosphorylated by Herpes Simplex Virus and incorporated into viral DNA. It stop DNA elongation. |
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Name 3 other anti-herpes drug.
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Valacyclovir (5x greater bioavailability)
Famciclovir (prodrug) --> Penciclovir (active form) Penciclovir is used as an ointment for cold sores. Ganciclovir |
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In addition to herpes, what is Ganciclovir used for?
What accounts for this phenomenon? |
It has increased activity against cytomegalovirus
CMV does not code for thymidine kinase, but viral protein kinase instead that phosphorylates Ganciclovir |
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What is unique about Hepatitis B (HBV)?
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Partially dsDNA
DNA polymerase has reverse transcription activity |
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How is HBV transmitted?
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Blood
Can cause liver damage and cancer |
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What is used to treat HBV?
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Lamivudine
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How does this drug work?
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Inhibits reverse transcriptase
Has made treatment of chronic HBV possible. Suppression is maintained for 2 years |
