Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Name the 2 non-selective adrenoceptor antagonists.
|
Labetolol
Carvedilol |
|
|
Name the 2 Alpha selective antagonists.
|
Phentolamine
Phenoxybenzamine |
|
|
Name the 4 Alpha 1 selective antagonists.
|
Prazosin
Doxazosin Terazosin Indoramine |
|
|
Name the 3 Alpha 2 selective antagonists.
|
Yohimbine
Rauwolscine Tolazoline |
|
|
Name the 7 Beta selective antagonists.
|
Propanolol
Carteolol Nadolol Penbutolol Pindolol Sotalol Timolol |
|
|
Name the 6 Beta 1 selective antagonists.
|
Acebutolol
Atenolol Betaxolol Celiprolol Esmolol Metoprolol |
|
|
Name the Beta 2 selective antagonist
|
Butoxamine
|
|
|
Name 5 cardiovascular effects of Alpha-antagonists.
|
Decreased TPR and BP
Epinephrine reversal Postural Hypotension Increase NE release (alpha 2 block) Compensatory increase in blood volume |
|
|
What are the genitourinary effects of alpha antagonists?
|
Relaxed prostate
Relaxed bladder sphincter/trigone |
|
|
Name two other effects of alpha antagonists.
|
Miosis (block of alpha 1 receptors to radial muscle)
Nasal stuffiness (increase blood flow to nose) |
|
|
Name 5 adverse effects of Alpha Antagonists.
|
Postural Hypotension
Tachycardia (reflex) Nasal stuffiness Impairment of ejaculation Sodium/Water retention (alpha 1 receptors increase renin release) |
|
|
Name the 7 adverse effects of Beta Antagonists.
|
CNS: Sedation, sleep disturbance, depression
Fatigue Asthma Depression of myocardial contractility Sexual dysfunction Rebound hypertension |
|
|
Name the 7 disease states that should avoid taking Beta antagonists.
|
Diabetes (unless Beta 1 selective)
Asthma PVD Bradyarrythmias/AV block Cardiac Disease Depression Impotence |
|
|
What are Beta antagonists used for clinically?
|
Hypertension (Beta 1 and 2)
Angina Pectoris (Decreased O2 demand) Cardiac Tachyarrythmias Glaucoma Hyperthyroidism (Cardiac effects of thyroid hormones blocked, decreased conversion of T4-T3) Migraine, anxiety, tremor, alcohol withdrawl |
|
|
What are alpha antagonists used for clinically?
|
Pheochromocytoma - lower BP
Hypertensive emergencies Chronic hypertension (alpha 1 preferred) PVD BPH ED |
|
|
Name the 5 Beta antagonists that have intrinsic sympathomimetic activity.
|
Pindolol
Acebutolol Carteolol Celiprolol Penbutolol |
|
|
What is the advantage of these drugs?
|
They block Beta 1 receptors and are useful against angina and hypertension. They are also partial agonists to Beta 2 receptors. They are less likely to cause bradycardia. Beta 2 agonism decreases BP and results in slight reflex stimulation?
|
|
|
This beta antagonist is noteworthy for its long duration.
|
Nadolol
|
|
|
This beta antagonist is ultra short acting and is used for controlling supraventricular arrhythmias, perioperative hypertension and myocardial ischemia
|
Esmolol
|
|
|
This beta non-selective drug has excellent ocular hypotensive effects.
|
Timolol
|
|
|
This antagonist is beta 1 selective, used in glaucoma and is less likely to cause broncho-constriction than non-selective agents.
|
Betaxolol
|
|
|
Antagonists of peripheral dopamine receptors have no clinical importance, but their CNS actions are important in these diseases.
|
Schizophrenia and other neuropsychiatric disorders.
|
