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42 Cards in this Set
- Front
- Back
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Dr Harvey Wiley becomes chief chemist in the Division of Chem of Agriculture dept. Responsible to prevent adulteration of agriculture products
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1883
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Wily put together "poison squad", young men who volunteered to eat foods treated w/measured amts of chemical preservatives to measure safety
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1902
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1906
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Pure Food and Drug Act (Wiley Act)
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Pure Food And Drug Act
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bureau of chemistry, prohibited misbranded or adulterated foods, drinks, or drugs and no false claims on labels. Required registration an listing of addicting substances
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1911
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Supreme Court ruled 1906 act did not prevent false therapeutic claims on labels
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1912
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Sherley amendment prohibited fraudulent therapeutic claims on labels
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Elixir of Sulfanilamide
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diethylene glycol, 107 deaths, helped FDC pass act of 1938
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1938 act
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Federal Food, Drug, and Cosmetic Act
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Federal Food, Drug, and Cosmetic Act
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required safety testing, accurate and complete labels, removed requirement of sherley amendment to prove intent to defraud, allowed factor inspections
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1951
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Durham Humphrey Amendment
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1951 Required what?
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Required statement, "caution: federal law prohibits dispensing without prescription" on all labels
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"caution: federal law prohibits dispensing without prescription" on all labels on what drugs?
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injection, hypnotics, narcotics, habit forming, toxic, investigational
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1951 created what?
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OTC
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1962
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Kefauver Harris Amendment
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Kefauver Harris Amendment
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testing for safety and effectiveness for new drugs and testing for those approved b/w 38 and 62
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1994
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dietary supplement health and education act
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dietary supplement health and education act does
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regulate labeling and therapeutic claims on dietary supplements
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dietary supplement health and education act does not
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require safety and effectiveness testing
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1998
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pediatric rule
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pediatric rule
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FDA requires manufacturers of new and existent biological products to assess safety and efficacy in children
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Where do drugs come from?
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natural, semi-synthetic, synthetic
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M1 Ach
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Gq
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NE alpha 1 adrenergic
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Gq
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5-HT2
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Gq
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NE Beta-1
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Gs
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NE Alpha 2
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Gi
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DA D1
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Gs
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DA D2
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Gi
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AMPA
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Cation channel
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GABA B
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Gi, Go
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5HT-1
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Gi
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5-HT3
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cation channel
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decrease adenylate cyclase
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Gi
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increase adenylate cyclase
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Gs
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Increase phospholipase C
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Gq
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Increase phospholipase A
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Gi
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increase Ca release from intracellular stores
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Gq
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Activate K channels in PM
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Gi
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Increase cAMP stimulated protein Kinase A
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Gs
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Increase DAG stimulated Protein kinase C
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Gq
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Nicotinic receptors
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cation channel
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kappa opoid receptor
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Gi, Go
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