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19 Cards in this Set
- Front
- Back
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Thiazide Diuretics Primary mechanisms of action��u8
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· Deplete Na+ (natriuesis) and reduce plasma volume.
act on distal tubule |
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A thiazide-like sulfonamidediuretic + ca channel blocker
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IndapamideRKu>
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· Prototype thiazide drug is
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hydrochlorothiazide.
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Side Effects of Thiazide Diuretics
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· Hypokalemia·
Dehydration Hyperglycemia: Possiblybecause of impaired insulin release secondary to hypokalemia. Becauseof this, ACE inhibitors are the first choice in diabetic patients with HT.· Hyperuricemia: Becausethiazides compete with urate for tubular secretion. Dangerin gout disease.· Hyperlipidemia: Mechanismunknown · Hyponatremia:Dueto thirst, sodium loss, inappropriate ADH secretion (can cause confusion in theelderly), usually after prolonged use"fo��u<;�c |
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why ACE inhibitors are the first choice in diabetic patients with HT |
Hyperglycemia: Possibly because of impaired insulin release secondary to hypokalemia. Because of this, ACE inhibitors are the first choice in diabetic patients with HT.
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name class 1 na ch blocker antiarrhythmic drugs |
quinidine procainamide disopyramidine |
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side effects of class 1 na ch blocker antiarrhythmic drugs |
procainidine=lupus like syndrome dissepyramidine=excelebrate heart failure quinidine=tinnitis, thrombocytopenia all of them prolong QT interval |
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whats the side of action of class 1 na ch blocker antiarrhythmic drugs |
act on atrium, ventricles and HIS |
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name class 1b antiarrhythmic drugs |
lidocaine phenetoin (antiepileptic) mexiletine |
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class 1b antiarrhythmic drugs used in which cases
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ischemia and ventricular arrhythmia, doesnt cause torsades |
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name class 1c antiarrhythmic drugs
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flekanaide propafenone |
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class 1c antiarrhythmic drugs used in which cases
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supraventricular and ventricular fibrillation, especially atrial fibrilation |
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side of action od class 2 antiarrhyhmics |
block SA and Av nodes, decrease cAMP, prolong phase 4 (beta blockers)
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side effects of class 2 antiarrhyhmics |
heart blockage, prolongation of QT |
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name class 3 antiarrhythimics |
k blockers till i die (dofetilide) ibutilide satalol amiadarone |
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which antiarrhythmic drug has effects of all 4 groups |
amiadarone |
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side effects of amiadarone |
hypo,hyperthyroid pulmonary fibross neurologic heart blockage heart failure hypersensetive hepatitis gray blue skin discoloration |
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name class 4 antihpertensive drugs |
ca channel blockersverapamilediltiazem
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side of action of class 4 antihpertensive drugs |
SA and Av nodes, use in supraventricular arrhythmia, especially a.fib |
