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16 Cards in this Set

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Factors affecting time course of IV injection to LOC

Ficks law


Rate of onset = rate of diffusion


Admin


Arm to brain blood


Brain blood to effect site


Effect site threshold of effect


Clearance

Isomers

Structural


- includes tautomers


Stereoisomers


- Geographic


- Optical - enantiomers


- Distereomers


Structural Isomers

Stereoisomers

Drugs with isomers

Structural


- enflurane and isoflurane


- dihydrocodeine and dobutamine



Tautomers


- thiopentone


- Midazolam



Geometric


- mivacurium - 3 isomers selective chemical reactions during production



Optical/enantiomers


- Bupivacaine


- ketamine


- Tramadol


- cisatracurium 1'R-cis 1'R-cis



Distereomers


- atracurium -> 4 chiral centres, 10 isomers



Therapeutic Index

Potency, efficacy, partial agonist, competitive antagonist

Pharmacology of ageing

PK changes in renal failure

Pharmacology of pregnancy

Half life

CSHT

Volume of distribution

Principles of TCI

Principles of Prop & Remi as TIVA

Principles of Sevo & Fentanyl as anaesthesia