Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
Bethanechol
|
DIRECT CHOLINERGIC AGONIST
Clinical App: Postoperative and neurogenic ileus and urinary retention. Action: Activates bowel and bladder smoot muscle; resistant to AchE |
|
|
Carbachol
|
DIRECT CHOLINERGIC AGONIST
Clinical App: glaucoma, pupillary contraction, and realease of intraocular pressure |
|
|
Pilocarpine
|
DIRECT CHOLINERGIC AGONIST
Clinical App: potent stimulator of sweat, tears, and saliva Action: Contracts ciliary muscle of eye (open angle), pupillary sphincter (narrow angle); resistant to AChE |
|
|
Methacholine
|
DIRECT CHOLINERGIC AGONIST
Clinical App: challenge test for diagnosis of asthma Action: stimulates muscarinic receptors in airway when inhaled. |
|
|
Neostigmine
|
INDIRECT CHOLINERGIC AGONIST (Anticholinesterase)
Clinical App: postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative) Action: increase endogenous Ach (no CNS penetration) NEO is NO CNS |
|
|
Pyridostigmine
|
INDIRECT CHOLINERGIC AGONIST (Anticholinesterase)
Clinical App:Myasthenia gravis (long acting); does not penetrate CNS. Action: increase endogenous Ach; increase strength |
|
|
Edrophonium
|
INDIRECT CHOLINERGIC AGONIST (Anticholinesterase)
Clinical App: diagnosis of myasthenia gravis (extremely short acting) Action: increase endogenous Ach |
|
|
Physostigmine
|
INDIRECT CHOLINERGIC AGONIST (Anticholinesterase)
Clinical App:glaucoma (crosses BBB into CNS) and atropine overdose Action: increase endogenous Ach PHYS is for EYES |
|
|
Echothiophate
|
INDIRECT CHOLINERGIC AGONIST (Anticholinesterase)
Clinical App:glaucoma Action: increase endogenous Ach |
|
|
Atropine
|
MUSCARINIC ANTAGONIST
Organ system: Eye, airway, stomach, gut, bladder Application: increase pupil dilation and cycloplegia; decrease airway and stomach acid secretions; decrease gut motility, decrease urgency in cystitis. Toxicity: increase body tempreature; rapid pulse, dry mouth, dry, flushed skin; cycloplegia, constipation; disorientation. Can cause acute angle-closure glaucoma in elderly, urinary retention in men with prostatic hypertrophy, and hyperthermia in infants. (Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter) |
|
|
Homatropine, Tropicamide
|
MUSCARINIC ANTAGONIST
Organ system: Eye Application: myadriasis and cycloplegia |
|
|
Benztropine
|
MUSCARINIC ANTAGONIST
Organ system: CNS Application: Parkinson's Disease PARK my BENZ |
|
|
Scopolamine
|
MUSCARINIC ANTAGONIST
Organ system: CNS Application: Motion sickness |
|
|
Ipratropium
|
MUSCARINIC ANTAGONIST
Organ system: Respiratory Application: Asthma; COPD |
|
|
Methscopolamine, oxybutinin, glycopyrrolate
|
MUSCARINIC ANTAGONIST
Organ system: Genitourinary Application: Reduce urgency in mild cystitis and reduce bladder spasms |
|
|
Pirenzepine, propatheline
|
MUSCARINIC ANTAGONIST
Organ system: Gastrointestinal Application: Peptic ulcer treatment |
|
|
Hexamethonium
|
NICOTINIC ANTAGONIST
Clnical use: ganglionic blocker. Used in experimental modesl to prevent vagal reflex responses to changes in blood pressure (eg prevents reflex brady cardia caused by NE) Toxicity: severe orthostatic hypotension, blurred vision, constipation, sexual dysfunction. |
