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9 Cards in this Set
- Front
- Back
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Floroquinones all have the same general MOA, what is it? What about their pharmacodymamics?
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Inhibition of DNA synthesis by inhibiting topoisomerases (DNA gyrase in G-, Topoisomerase IV in G+)
They are concentration-dependent killers |
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What are three of the drug-drug interactions of Floroquinones?
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Cations (Ca, Mg, Fe, Zn, Al) so watch eating and supplement times
Warfarin (increased efficacy) Cyclosporine and Theophylines |
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What are the absorption and distribution routes for the Floroquinones?
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Levo and Moxi have good oral absorption.
All the Floroquinones distribute widely throughout the body. |
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What are some of the adverse effects of Floroquinones?
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Hepatotoxicicty
Increased QT interval Cartilage damage (done use in kids or preggo's) Tendon rupture (rare) |
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What Floroquinones are eliminated renaly?
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Cipro and Levo
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What Floroquinones are eliminated hepaticly?
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Moxi (so not for what...)
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What infections are indications for Cipro?
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Nosocomial infections such as: S. Pneumo, infections in cystic fibrosis, UTI's
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What infections are indications for Levo and Moxi?
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CAP, TB (resistant), atypical pneumonia
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What is the spectrum of activity for Floroquinones?
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G(+): MSSA, S. Pneumo, Limited: Group strep's, Claustridium, Bacteroides
G(-): Entero's, H. Influenzae, P. Aeurginosa (not moxi) Atypicals: Legionalla Pneumonia, Chlamydia, Mycoplasma, Ureaplasma |
